NCT07248202Completed
Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia in Patients With Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass
A Comparison Between the Effect of Ketamine-lidocaine Versus Ketamine-fentanyl for Induction of Anesthesia on Cerebral Perfusion Guided by Near Infra-red Spectroscopy in Patients With Coronary Artery Disease and Left Ventricular Systolic Dysfunction Undergoing Elective Coronary Artery Bypass Graft Surgery: (A Randomized Controlled Study)
Source: ClinicalTrials.gov · Last updated 7 Aug 2026
Brief summary (registry, in English)
This study compares ketamine/fentanyl versus ketamine/lidocaine in term of their impact on cerebral perfusion during CABG. No prior data address these effects, and the goal is to identify the induction regimen that better preserves cerebral oxygenation.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 48 (actual)
- First submitted
- 18 Nov 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 25 Jun 2026
- Lead sponsor
- Cairo University
- Diseases
- Coronary artery disease
- NCT number
- NCT07248202
What you commit to
- Study type: Interventional
- Participants enrolled: 48
- From 1 Dec 2025 to the primary completion date, 25 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- emergency surgery,
Other illness
- associated chronic stroke, TIA , carotid occlusive disease( due to abnormal vasomotor activity), patients with known neurological impairment (cerebral infarction , dementia ), significant carotid artery stenosis ,
- valvular heart disease,
- persistent arrhythmias,
- congestive cardiac failure,
- and those with known allergy to any of the study's drugs,
- severe systemic non-cardiac disease and
- Patients with dementia or visual or auditory impairment
Other
- on mechanical ventilation,
- intra-aortic balloon pump,
- patients with baseline NIRS reading \< 60%
Who the study is looking for
- patients with coronary artery disease
- with moderate to severe left ventricular dysfunction (ejection fraction \< 40%),
- scheduled for elective CABG surgery
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kasr Alainy hospital Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.