NCT07249138Completed
Impact of Congenital Heart Disease on the Prognosis of Childhood Hematological Neoplasms: A Multicenter Cohort Study
Impact of Congenital Heart Disease on Quality of Life and Long-Term Outcomes in Childhood Hematological Tumor Survivors
Source: ClinicalTrials.gov · Last updated 25 Nov 2025
Brief summary (registry, in English)
This study aims to determine whether congenital heart disease increases chronic health risks and mortality in childhood hematological tumor survivors, explore potential shared genetic factors between these conditions, identify other factors affecting long-term outcomes and quality of life, and validate any discovered genetic links through mechanistic investigations.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 800 (actual)
- First submitted
- 18 Nov 2025
- Start date
- 15 Feb 2025
- Primary completion date
- 10 Nov 2025
- Lead sponsor
- Children's Hospital of Fudan University
- Diseases
- Childhood cancers
- NCT number
- NCT07249138
What you commit to
- Study type: Observational
- Participants enrolled: 800
- From 15 Feb 2025 to the primary completion date, 10 Nov 2025
- 18 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of birth defects other than congenital heart disease;
- Other serious cardiac conditions, malignancies, or comorbidities that may interfere with study results;
Other
- Inability to provide the information and data required for the study.
Who the study is looking for
- Children with hematologic malignancies diagnosed by pathology or bone marrow aspiration/biopsy at member hospitals of the Hematologic Oncology Specialty Alliance between 2010 and 2025;
- Aged 0-17 years at diagnosis, regardless of gender;
- Completed standard treatment for hematologic malignancies and confirmed diagnosis of congenital heart disease by cardiac ultrasound and clinical evaluation;
- Written informed consent can be provided by the child or their legal guardian.
Age in the registry: 0 weeks to 18 years · Sex: All · Does not accept healthy volunteers
Sites (18)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Beijing Children's Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| The Third Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Unknown status |
| Guangzhou Women and Children's medical center Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
| Inner Mongolia Maternal and Child Health Care Hospital Coordinator of this site? Confirm its status | Hohhot | China | Unknown status |
| Shandong Provincial Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| Nanjing Children's Hospital Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The First Affiliated Hospital of Guangxi Medical University Coordinator of this site? Confirm its status | Nanning | China | Unknown status |
| The Affiliated Hospital of Qingdao University Coordinator of this site? Confirm its status | Qingdao | China | Unknown status |
| Shanghai Children's HospitalShanghai Children's Hospital Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| Children's Hospital Of Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
| The Fourth Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Unknown status |
| Children's Hospital of Soochow University Coordinator of this site? Confirm its status | Suzhou | China | Unknown status |
| Shanxi Children's Hospital Coordinator of this site? Confirm its status | Taiyuan | China | Unknown status |
| Union Hospital of Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Tongji Hospital of Huazhong University of Science and Technology Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Wuhan Children's Hospital Coordinator of this site? Confirm its status | Wuhan | China | Unknown status |
| Northwest Women's and Children's Hospital Coordinator of this site? Confirm its status | Xi'an | China | Unknown status |
| The First Affiliated Hospital of Zhengzhou University Coordinator of this site? Confirm its status | Zhengzhou | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.