NCT07250464Not yet recruiting
Motor Evoked Potential and Cortical Silent Period in Migraine
Investigation of Motor Evoked Potential and Cortical Silent Period in Migraine Patients
Source: ClinicalTrials.gov · Last updated 28 Nov 2025
Brief summary (registry, in English)
The primary objective of this study is to assess the level of inhibitory control in the motor cortex of migraine patients using objective and non-invasive methods. To this end, Motor Evoked Potential (MEP) and Cortical Silence Period (CSP) parameters obtained using Transcranial Magnetic Stimulation (TMS) will be measured and comparisons will be made between migraine patients and healthy controls. Since CSP duration is used specifically in the evaluation of GABA-B-mediated inhibitory mechanisms, it has the potential to directly measure the effect of migraine on cortical inhibition.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- Dec 2025
- Primary completion date
- Jan 2026
- Lead sponsor
- Istanbul Gelisim University
- Diseases
- Migraine
- NCT number
- NCT07250464
What you commit to
- Study type: Interventional
- Planned participants: 20
- From Dec 2025 to the primary completion date, Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Presence of metal implants, pacemakers, or other contraindications to TMS.
- Use of medications that significantly alter cortical excitability (e.g., antiepileptics, benzodiazepines) in the last 2 weeks.
Other illness
- History of epilepsy or other seizure disorders.
- History of significant neurological or psychiatric disorders.
- Any musculoskeletal condition preventing safe participation in EMG/TMS procedures.
Other
- Pregnancy or breastfeeding.
Who the study is looking for
- Age 18-45 years.
- Right-handed individuals.
- Migraine patients: diagnosed according to International Headache Society (IHS) criteria.
- Healthy controls: no history of migraine or other neurological disorders.
- Able and willing to provide informed consent.
Age in the registry: 18 years to 45 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Istanbul Gelisim University, Faculty of Dentistry, Translational Dentistry Research Laboratory Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.