NCT07250893Recruiting
Resolving Early Life Stress: Psychotherapy Outcomes and Neurobiology in Complex Depression
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
The RESPOND trial explores the link between early life adversity and later life depressive symptoms. The investigators have designed a new psychological therapy tailored to address the symptoms that can be caused by difficult experiences in early life. These symptoms include low mood, emotional dysregulation, and distressing thoughts and beliefs related to difficult or traumatic experiences. The investigators would like to see if this new therapy helps people feel better. The investigators are also studying the biological changes that can occur as a result of early life adversity, and how this therapy may influence those changes. To do this, the investigators ask questions about participants' physical and mental health and take blood samples.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 8 Apr 2025
- Start date
- 25 Oct 2025
- Primary completion date
- 15 Aug 2027
- Lead sponsor
- St. Joseph's Healthcare Hamilton
- Diseases
- Depression
- NCT number
- NCT07250893
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 25 Oct 2025 to the primary completion date, 15 Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Individuals who meet for PTSD diagnosis from a criterion A trauma occurring in adulthood without a history of ELA
- Individuals with an active substance use disorder
Other
- Individuals experiencing active mania or psychosis
- Individuals presenting with active suicide risk (plan, intention, means) indicative of a need for higher level care
- Individuals in current psychotherapeutic treatment (defined as having engaged in consistent psychotherapy within the last 3 months)
Who the study is looking for
- Adults 18 years old or older
- At or above 18 on HAM-D, indicative of moderate-severe depressive symptoms
- Any childhood (before 18 years old) adversity as indicated by scores on the CECA q and ACES q
Age in the registry: 18 years to 65 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Joseph's Healthcare Hamilton Coordinator of this site? Confirm its status | Hamilton | Canada | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.