NCT07251231Not yet recruiting
Effectiveness of Virtual Reality in Parkinson's Disease: Effects on Balance, Fall Risk, and Exercise Capacity.
Effectiveness of Virtual Reality in Parkinson's Disease: Impact on Balance, Fall Risk, and Cardiorespiratory Exercise Capacity.
Source: ClinicalTrials.gov · Last updated 28 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate whether immersive virtual reality (VR)-based physiotherapy is effective in improving balance, reducing fall risk, and enhancing cardiorespiratory exercise capacity in individuals with Parkinson's disease. The main questions it aims to answer are: Does immersive VR therapy improve postural balance more effectively than conventional physiotherapy? Does immersive VR reduce fall risk and increase cardiorespiratory fitness compared with standard physiotherapy? Researchers will compare an immersive VR intervention with conventional physiotherapy to determine whether VR can produce superior functional and physiological outcomes in patients with Parkinson's disease. Participants will: Be randomly assigned (1:1) to an experimental group (immersive VR therapy) or a control group (conventional physiotherapy). Take part in structured physiotherapy sessions focused on balance, mobility, and functional capacity. Undergo pre- and post-intervention assessments of balance, fall risk, cardiorespiratory exercise capacity, and quality of life. This randomized controlled trial (RCT) with parallel assignment will include 50 participants (25 per group). Randomization will be performed using the OxMaR (Oxford Minimization and Randomization) software, which enables adaptive randomization to ensure balanced baseline characteristics between groups. Secondary objectives include evaluating the impact of immersive VR on health-related quality of life and comparing treatment adherence between VR-based and conventional physiotherapy interventions.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 50 (estimated)
- First submitted
- 18 Nov 2025
- Start date
- 30 May 2026
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- University of Valencia
- Diseases
- Parkinson disease
- NCT number
- NCT07251231
What you commit to
- Study type: Interventional
- Planned participants: 50
- From 30 May 2026 to the primary completion date, 30 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Adverse effects related to the intervention, including severe dizziness, persistent nausea, disorientation, or headaches that prevent continuation of therapy.
Other illness
- Severe cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score \< 21.
- Visual or vestibular disorders that would compromise safe use of virtual reality equipment.
- Serious medical complications during the study (e.g., acute cardiovascular events such as myocardial infarction or stroke) that may endanger the participant or interfere with treatment.
- Surgical or medical procedures unrelated to Parkinson's disease that affect general mobility or the ability to participate in the intervention.
Other
- Severe musculoskeletal comorbidities that limit mobility or prevent participation in physiotherapy sessions.
- Lack of adherence to the protocol, defined as missing four or more intervention sessions without justification.
- Significant worsening of neurological status or new complications that contraindicate participation in physiotherapy.
Who the study is looking for
- Age between 55 and 75 years.
- Clinical diagnosis of Parkinson's disease confirmed by a neurologist.
- Mild to moderate disease stage (Hoehn and Yahr I-III).
- Ability to understand and follow simple instructions and actively participate in the intervention.
- Signed informed consent provided before participation.
Age in the registry: 55 years to 75 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Faculty of Physiotherapy. University of Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.