NCT07252232RecruitingPhase 3
Study of Daraxonrasib (RMC-6236) in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
RASolute 304: A Phase 3 Multicenter, Open-label, Randomized, 2-Arm Study of Adjuvant Daraxonrasib Versus Standard of Care Observation Following Completion of Neoadjuvant and/or Adjuvant Chemotherapy in Patients With Resected Pancreatic Ductal Adenocarcinoma (PDAC)
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to evaluate the safety and efficacy of a novel RAS(ON) inhibitor compared to standard of care (SOC) observation only.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 500 (estimated)
- First submitted
- 13 Nov 2025
- Start date
- 15 Dec 2025
- Primary completion date
- 10 May 2029
- Lead sponsor
- Revolution Medicines, Inc.
- Diseases
- Pancreatic cancer
- NCT number
- NCT07252232
- EU CT number
- 2025-523495-23-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 500
- From 15 Dec 2025 to the primary completion date, 10 May 2029
- 91 sites in 10 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior therapy with direct RAS-targeted therapy (eg. degraders and/or inhibitors).
- Major surgery within 28 days prior to randomization.
Other illness
- Any conditions that may affect the ability to take or absorb study drug.
Other
- Patient is unable or unwilling to comply with protocol-required study visits or procedures.
Who the study is looking for
- At least 18 years old and has provided informed consent.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
- Histologically confirmed PDAC with successful (R0/R1) curative intent surgical resection and no evidence of recurrent or metastatic disease.
- Must have received perioperative (neoadjuvant, adjuvant, or a combination of both) multi-agent chemotherapy.
- Must have completed most recent treatment within the past 12 weeks.
- Adequate organ function (bone marrow, liver, kidney, coagulation).
- Documented RAS mutation status.
- Able to take oral medications.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (91)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| McGill University Health Centre Coordinator of this site? Confirm its status | Montreal | Canada | Recruiting |
| Princess Margaret Cancer Centre - University Health Network Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Sana Kliniken Berlin-Brandenburg GmbH Coordinator of this site? Confirm its status | Berlin | Germany | Recruiting |
| Krankenhaus Nordwest GmbH Coordinator of this site? Confirm its status | Frankfurt am Main | Germany | Recruiting |
| Universitaetsklinikum Heidelberg AöR Coordinator of this site? Confirm its status | Heidelberg | Germany | Recruiting |
| Universitaetsklinikum Schleswig-Holstein AöR Coordinator of this site? Confirm its status | Luebeck | Germany | Recruiting |
| LMU Klinikum Muenchen AöR Coordinator of this site? Confirm its status | Munich | Germany | Recruiting |
| Universitaetsklinikum Ulm AoR Coordinator of this site? Confirm its status | Ulm | Germany | Recruiting |
| Hospital Clinic de Barcelona Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitario 12 de Octubre Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Clínica Universidad de navarra Coordinator of this site? Confirm its status | Pamplona | Spain | Recruiting |
| University Hospital Virgen Del Rocio S.L. Coordinator of this site? Confirm its status | Sevilla | Spain | Recruiting |
| Hospital Clinico Universitario de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| Hospital Universitario Miguel Servet Coordinator of this site? Confirm its status | Zaragoza | Spain | Recruiting |
| Centre Hospitalier Universitaire De Lille Coordinator of this site? Confirm its status | Lille Cedex | France | Recruiting |
| Hospital Edouard Herriot Coordinator of this site? Confirm its status | Lyon Cedex 03 | France | Recruiting |
| Institut Paoli-Calmettes Coordinator of this site? Confirm its status | Marseille | France | Recruiting |
| Centre De Lutte Contre Le Cancer Eugene Marquis Coordinator of this site? Confirm its status | Rennes Cedex | France | Recruiting |
| Institut Gustave Roussy Coordinator of this site? Confirm its status | Villejuif | France | Recruiting |
| Hopital Paul Brousse Coordinator of this site? Confirm its status | Villejuif Cedex | France | Recruiting |
| University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Medical Centre Coordinator of this site? Confirm its status | Birmingham | United Kingdom | Recruiting |
| Beatson West of Scotland Cancer Centre Coordinator of this site? Confirm its status | Glasgow | United Kingdom | Recruiting |
| Clatterbridge Cancer Centre NHS Foundation Trust Coordinator of this site? Confirm its status | Liverpool | United Kingdom | Recruiting |
| Imperial College Healthcare NHS Foundation Trust, Hammersmith Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| The Royal Marsden NHS Foundation Trust, Royal Marsden Hospital-London Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| The Christie NHS Foundation Trust Coordinator of this site? Confirm its status | Manchester | United Kingdom | Recruiting |
| Istituto Europeo di Oncologia s.r.l Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Fondazione IRCCS - Istituto Nazionale dei Tumori Coordinator of this site? Confirm its status | Milan | Italy | Recruiting |
| Azienda Ospedaliera Universitaria - Universita degli Studi della Campania Luigi Vanvitelli Coordinator of this site? Confirm its status | Naples | Italy | Recruiting |
| Istituto Oncologico Veneto Coordinator of this site? Confirm its status | Padova | Italy | Recruiting |
| Azienda Ospedaliero Universitaria Pisana Coordinator of this site? Confirm its status | Pisa | Italy | Recruiting |
| Fondazione Policlinico Universitario Agostino Gemelli IRCCS Coordinator of this site? Confirm its status | Rome | Italy | Recruiting |
| Centro Ricerche Cliniche di Verona s.r.l. Coordinator of this site? Confirm its status | Verona | Italy | Recruiting |
| National Cancer Center Hospital East Coordinator of this site? Confirm its status | Chiba | Japan | Recruiting |
| Kyushu University Hospital Coordinator of this site? Confirm its status | Fukuoka | Japan | Recruiting |
| Kyoto University Hospital Coordinator of this site? Confirm its status | Kyoto | Japan | Recruiting |
| Cancer Institute Hospital of JFCR Coordinator of this site? Confirm its status | Tokyo | Japan | Recruiting |
| National Cancer Center Hospital Coordinator of this site? Confirm its status | Tokyo | Japan | Recruiting |
| Kanagawa Cancer Center Coordinator of this site? Confirm its status | Yokohama | Japan | Recruiting |
| Dong-A University Hospital Coordinator of this site? Confirm its status | Busan | South Korea | Recruiting |
| Asan Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Seoul National University Hospital Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Samsung Medical Center Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| Pan American Oncology Trials, LLC Coordinator of this site? Confirm its status | San Juan | Puerto Rico | Recruiting |
| Piedmont Physicians Medical Oncology Atlanta Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Winship Cancer Institute, Emory University Coordinator of this site? Confirm its status | Atlanta | United States | Recruiting |
| Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins & Sibley Memorial Hospital Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| The University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Recruiting |
| Massachusetts General Hospital Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Dana-Farber Cancer Institute (DFCI) Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| University of Texas Southwestern Medical Center Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Texas Oncology - DFW Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Duke Cancer Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
| Virginia Cancer Specialists Coordinator of this site? Confirm its status | Fairfax | United States | Recruiting |
| Hartford Healthcare Coordinator of this site? Confirm its status | Hartford | United States | Recruiting |
| University of Texas - MD Anderson Cancer Center Coordinator of this site? Confirm its status | Houston | United States | Not yet recruiting |
| Community Health Network Coordinator of this site? Confirm its status | Indianapolis | United States | Recruiting |
| Mayo Clinic Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Saint Luke's Cancer Institute Coordinator of this site? Confirm its status | Kansas City | United States | Recruiting |
| UC San Diego Moores Cancer Center Coordinator of this site? Confirm its status | La Jolla | United States | Recruiting |
| Rocky Mountain Cancer Centers LLP Coordinator of this site? Confirm its status | Lakewood | United States | Recruiting |
| Comprehensive Cancer Centers of Nevada Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| University of Kansas Medical Center Research Institute, Inc. Coordinator of this site? Confirm its status | Lawrence | United States | Recruiting |
| Texas Oncology - Northeast Texas Coordinator of this site? Confirm its status | Longview | United States | Recruiting |
| University of California, Los Angeles Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center Coordinator of this site? Confirm its status | Los Angeles | United States | Recruiting |
| Taylor Cancer Research Center Coordinator of this site? Confirm its status | Maumee | United States | Recruiting |
| University of Miami Hospital and Clinics Sylvester Comprehensive Cancer Center Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Mount Sinai Braman Comprehensive Cancer Center Coordinator of this site? Confirm its status | Miami Beach | United States | Recruiting |
| Froedtert Hospital and the Medical College of Wisconsin Coordinator of this site? Confirm its status | Milwaukee | United States | Recruiting |
| SCRI Oncology Partners Coordinator of this site? Confirm its status | Nashville | United States | Recruiting |
| Rutgers Cancer Institute Coordinator of this site? Confirm its status | New Brunswick | United States | Recruiting |
| Columbia University Medical Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Icahn School of Medicine at Mount Sinai Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Memorial Sloan-Kettering Cancer Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| Laura and Issac Perlmutter Cancer Center at NYU Langone-Ambulatory Care Center Coordinator of this site? Confirm its status | New York | United States | Recruiting |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Recruiting |
| Stanford Cancer Institute Coordinator of this site? Confirm its status | Palo Alto | United States | Recruiting |
| University of Pennsylvania/Abramson Cancer Center Coordinator of this site? Confirm its status | Philadelphia | United States | Recruiting |
| Mayo Clinic Coordinator of this site? Confirm its status | Phoenix | United States | Recruiting |
| UPMC Hillman Cancer Center Coordinator of this site? Confirm its status | Pittsburgh | United States | Recruiting |
| University of Rochester Medical Center Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| Mayo Clinic Cancer Center Coordinator of this site? Confirm its status | Rochester | United States | Recruiting |
| University of California Davis Comprehensive Cancer Center Coordinator of this site? Confirm its status | Sacramento | United States | Recruiting |
| University of Utah - Huntsman Cancer Institute Coordinator of this site? Confirm its status | Salt Lake City | United States | Recruiting |
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| HonorHealth Research Institute Coordinator of this site? Confirm its status | Scottsdale | United States | Recruiting |
| Fred Hutchison Cancer Center Coordinator of this site? Confirm its status | Seattle | United States | Recruiting |
| Avera Cancer Institute Coordinator of this site? Confirm its status | Sioux Falls | United States | Recruiting |
| Florida Cancer Specialists Coordinator of this site? Confirm its status | St. Petersburg | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.