Pilot Study of StudyU for N-of-1 Trials in HFrEF Patients (N-of-1 App)

Prior treatment

• Clinical instability (this N-of-trial is appropriate for stable conditions only)
  • Decompensated HF
  • Hospitalized in the past 30 days
  • Medication changes or procedures in prior 14 days (to prevent confounding from other interventions) at PI discretion

Other illness

• Moderate-severe dementia or psychiatric disorder precluding informed consent
• History of noncompliance or inability to complete study procedures
• Any condition that, in Principal Investigator or treating physician's opinion, makes the patient unsuitable for study participation

Other

• Do not have access to a smartphone or tablet
• Estimated life expectancy \<6 months
• Language barrier that will preclude informed consent and ability to comprehend study procedures
• Enrollment in a clinical trial not approved for co-enrollment

• Adults ≥ 65 years old
• A history of HFrEF per electronic medical record review/clinician impression that is defined as an EF \<50% that is shown from any imaging modality
• Taking less than the maximal dose of beta blocker per physician recommendation at time of enrollment
• Access to a smartphone or device that can perform many of the same functions as a computer, typically having a touchscreen interface, internet access, and an operating system capable of running downloaded applications