NCT07252557Not yet recruiting
Mouthwash Temperature and Oral Mucositis in Head and Neck Radiotherapy
Effectiveness of Different Mouthwash Temperatures on Oral Mucositis Pain and Patient Comfort During Radiotherapy for Head and Neck Cancer: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 26 Nov 2025
Brief summary (registry, in English)
This single-center randomized controlled trial evaluates the effects of cold (15-20°C) versus room-temperature (30-35°C) water gargling on oral mucositis severity, pain, and comfort in patients with head and neck cancer undergoing radiotherapy. Participants will rinse their mouth four times daily for 30-60 seconds over a 6-week radiotherapy course, with follow-up for two additional weeks. The study hypothesizes that cold-water rinsing can reduce the severity of radiation-induced oral mucositis (RTOM) and pain, improve oral comfort, and minimize treatment interruptions.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 18 Nov 2025
- Start date
- Jan 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- Chung Shan Medical University
- Diseases
- Head and neck cancer
- NCT number
- NCT07252557
What you commit to
- Study type: Interventional
- Planned participants: 200
- From Jan 2026 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Non-HNC diagnoses or radiotherapy to sites outside the oral/oropharyngeal region.
Other illness
- Cognitive impairment or inability to complete the rinsing protocol.
Who the study is looking for
- Histologically confirmed head and neck cancer (HNC) receiving radiotherapy for the first time, with or without concurrent chemotherapy.
- Conscious, communicative, and able to perform the rinsing procedure and complete questionnaires.
- Provided written informed consent prior to enrollment.
Age in the registry: 20 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chung Shan Medical University Coordinator of this site? Confirm its status | Taichung | Taiwan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.