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NCT07253870Recruiting

Comperative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation in Subacute Stroke Patients

Comparative Effects of Transcutaneous Auricular and Cervical Vagus Nerve Stimulation on Upper Limb Function, Cognition and Quality of Life in Subacute Stroke Patients

Source: ClinicalTrials.gov · Last updated 18 Jun 2026

Brief summary (registry, in English)

This study aims to determine whether transcutaneous vagus nerve stimulation (tVNS) via auricular or cervical branches enhances recovery when combined with task-specific training in subacute stroke patients. We anticipate finding that both stimulation methods may improve upper limb motor function compared to conventional therapy. The research is expected to reveal specific cognitive domains (attention, memory, executive function) that benefit most from each stimulation approach, while also demonstrating meaningful improvements in patients' quality of life measures. These findings may make a significant practical contribution by providing clinicians with evidence-based guidance on suitable tVNS approach for improving functional independence and quality of life for stroke survivors.

Status (registry)
Recruiting
Study type
Interventional
Enrollment
54 (estimated)
First submitted
19 Nov 2025
Start date
20 Nov 2025
Primary completion date
20 Jun 2026
Lead sponsor
Lahore University of Biological and Applied Sciences
Diseases
Stroke
NCT number
NCT07253870

What you commit to

  • Study type: Interventional
  • Planned participants: 54
  • From 20 Nov 2025 to the primary completion date, 20 Jun 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Previous injury or surgical intervention of vagus nerve

Other illness

  • Patients with cardiac arrest and arrythmias
  • Uncontrolled hypertension
  • Other neurologic or musculoskeletal diseases

Other

  • Apraxia
  • Presence of implanted electronic devices

Who the study is looking for

  • First ever ischemic stroke
  • Subacute phase of stroke 3-6 months post onset
  • Fugl-Meyer Assessment-Upper Extremity (FMA-UE) scores ranged from 20 - 50

Age in the registry: 45 years to 70 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Save your city in your profile to sort them by distance.

SiteCityCountrySite status
Shadman Medical Center, Stroke Rehabilitation
Coordinator of this site? Confirm its status
LahorePakistanRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.