NCT07255469Recruiting
Metabolic Fluid Responsiveness in Children
Parameters Associated With Metabolic Response to Volume Expansion in Children Post-operative of Cardiac Surgery
Source: ClinicalTrials.gov · Last updated 1 Dec 2025
Brief summary (registry, in English)
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery. This would allow physicians to identify which patient could benefit the most from fluid expansion, thus avoiding useless and potentially dangerous fluid expansions that could lead to fluid overload. To this end, The investigators will evaluate the diagnostic accuracy of the ratio of central venous to arterial carbon dioxide tension (Pv-aCO2) to arteriovenous oxygen content (CavO2), a simple biological marker of anaerobic metabolism, for the diagnosis of metabolic fluid responsiveness defined as a significant increase in oxygen consumption (VO2) after fluid expansion.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 110 (estimated)
- First submitted
- 1 Sept 2025
- Start date
- 21 Mar 2025
- Primary completion date
- 21 Mar 2027
- Lead sponsor
- University Hospital, Bordeaux
- NCT number
- NCT07255469
What you commit to
- Study type: Observational
- Planned participants: 110
- From 21 Mar 2025 to the primary completion date, 21 Mar 2027
- 8 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Impairment of echocardiographic acoustic window or restless patient making ultrasonography impossible
Age
- Patient less than 37 weeks' corrected gestational age
Other
- Hemodynamic instability making the delay necessary for any test dangerous
- Supine position contraindicated or deleterious
- Opposition to participate expressed by the patient or by a parent or legal guardian
Who the study is looking for
- Age less than or equal to 15 years old
- Hospitalization in a pediatric intensive care unit after cardiac surgery
- Prescription by the attending physician of a fluid expansion of 10ml/kg
- Prescription of arterial and venous blood gas before and after the volume expansion to help manage acute circulatory failure
- Patient implanted with a functioning arterial line
- Patient implanted with a functioning central venous line in the superior vena cava territory
Age in the registry: 0 days to 15 years · Sex: All · Does not accept healthy volunteers
Sites (8)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Louis Pradel, Hospices Civils de Lyon Coordinator of this site? Confirm its status | Bron | France | Recruiting |
| Hôpital Jeanne de Flandre - CHU de Lille Coordinator of this site? Confirm its status | Lille | France | Recruiting |
| Hôpital de la Timone - Assistance Publique - Hôpitaux de Marseille Coordinator of this site? Confirm its status | Marseille | France | Not yet recruiting |
| Hôpital mère-enfant - CHU de Nantes Coordinator of this site? Confirm its status | Nantes | France | Recruiting |
| Hôpital Necker-Enfants Malades - Assistance Publique - Hôpitaux de Paris Coordinator of this site? Confirm its status | Paris | France | Recruiting |
| Hôpital Cardiologique Haut Lévêque - CHU de Bordeaux Coordinator of this site? Confirm its status | Pessac | France | Recruiting |
| Hôpital Felix Guyon - CHU de la Réunion Coordinator of this site? Confirm its status | Saint-Denis | France | Recruiting |
| Hôpital des Enfants - CHU de Toulouse Coordinator of this site? Confirm its status | Toulouse | France | Not yet recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.