NCT07256418Recruiting
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Source: ClinicalTrials.gov · Last updated 29 Jan 2026
Brief summary (registry, in English)
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 20 Nov 2025
- Start date
- 26 Jan 2026
- Primary completion date
- Jan 2027
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Diseases
- Systemic sclerosis (scleroderma)
- NCT number
- NCT07256418
What you commit to
- Study type: Observational
- Planned participants: 60
- From 26 Jan 2026 to the primary completion date, Jan 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases
Other
- FOR PATIENTS WITH SCLERODERMA :
- Person not affiliated to or not benefiting from a social security scheme
- Person subject to a legal protection measure (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
- FOR CONTROLLED PARTICIPANTS :
- Person not affiliated to or not benefiting from a social security scheme
- Person under legal protection (curatorship, guardianship)
- Person subject to a legal protection measure
- An adult who is incapable or unable to give consent
- Minors
Who the study is looking for
- FOR PATIENTS WITH SCLERODERMA :
- Person who has given written consent
- Person with systemic scleroderma
- FOR CONTROL PARTICIPANTS :
- Person who has given written consent
- Person undergoing plastic, cosmetic and reconstructive surgery
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Chu Dijon Bourgogne Coordinator of this site? Confirm its status | Dijon | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.