NCT07258628Completed
Comparison of Fentanyl and Magnesium to Control Reflex Hemodynamics in Patients Aged 50 and Older
Magnesium and Fentanyl in Preventing Reflex Hemodynamic Response to Endotracheal Intubation in Patients Aged 50 Years and Older
Source: ClinicalTrials.gov · Last updated 19 Mar 2026
Brief summary (registry, in English)
This prospective, randomized, controlled trial aims to evaluate the effects of magnesium sulfate and fentanyl on the hemodynamic response to endotracheal intubation in surgical patients aged 50 years and older. A total of 75 patients will be enrolled and randomized into three groups: magnesium sulfate alone, magnesium sulfate plus fentanyl, and fentanyl alone. The primary outcome measures are changes in mean arterial pressure (MAP) and heart rate before and after intubation. Secondary outcomes include BIS, SEF, ST, TOF recovery times, intraoperative hemodynamic stability, and perioperative complications.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 76 (actual)
- First submitted
- 19 Sept 2025
- Start date
- 10 Oct 2025
- Primary completion date
- 10 Jan 2026
- Lead sponsor
- Ankara City Hospital Bilkent
- Diseases
- High blood pressure
- NCT number
- NCT07258628
What you commit to
- Study type: Interventional
- Participants enrolled: 76
- From 10 Oct 2025 to the primary completion date, 10 Jan 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Known renal or hepatic insufficiency
- Uncontrolled hypertension
- Suspected difficult airway (Mallampati ≥ 3 or history of difficult intubation)
- Known allergy or hypersensitivity to study medications
- Myocardial infarction within the past 3 months
- Presence of heart block
Other
- Thyroid dysfunction
- Preoperative hypermagnesemia
- Withdrawal Criteria:
- Laryngoscopy time exceeding 20 seconds
- Withdrawal of informed consent
- Patient withdrawal from the study at any time
Who the study is looking for
- Age ≥ 50 years
- Patients scheduled for elective surgery under general anesthesia
- Patients requiring endotracheal intubation with a single-lumen tube
- Provision of written informed consent
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Ankara City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
| Ankara Bilkent City Hospital, Department of Anesthesiology and Reanimation Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.