NCT07259512RecruitingPhase 4
Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure
Comparative Effects of Single Versus Twice-Daily Ramipril Dosing on Renal Function in Patients With Chronic Kidney Disease and Heart Failure With Reduced Ejection Fraction: Evaluation of Plasma Renin Activity, Malondialdehyde, Interleukin-6, Albuminuria, and Cystatin C
Source: ClinicalTrials.gov · Last updated 10 Dec 2025
Brief summary (registry, in English)
This study compares the effects of once-daily versus twice-daily ramipril dosing on renal function in chronic kidney disease (CKD) patients with heart failure with reduced ejection fraction (HFrEF). Outcomes include changes in plasma renin activity, malondialdehyde, interleukin-6, albuminuria, and cystatin C after 30 days of therapy.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 20 Nov 2025
- Start date
- 30 Jun 2025
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Evi Liliek Wulandari
- Diseases
- Chronic kidney disease, Heart failure
- NCT number
- NCT07259512
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 80
- From 30 Jun 2025 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receiving hemodialysis therapy
- Receiving sacubitril-valsartan therapy
- Receiving ARB therapy
Other illness
- History of intolerance to ACE inhibitors
- History of angioedema to ACE inhibitors
Other
- Refractory hyperkalemia
- Pregnancy
- Hypotension with blood pressure \<90/60, or patients in shock.
Who the study is looking for
- Female or Male with age \>18 years old
- Patients with a diagnosis of CKD stage 3-5 non-dialysis with low ejection fraction heart failure (ejection fraction \< 40%)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UNS Hospital Coordinator of this site? Confirm its status | Kartasura | Indonesia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.