Comparison of the Amplatzer Amulet Versus LAmbre Device for Left Atrial Appendage Closure

Prior treatment

• Patient with requirement for oral anticoagulation therapy for any indication other than non-valvular atrial fibrillation.
• Patient with prior surgical ligation or obliteration of the left atrial appendage.
• Patient with concurrent participation in another investigational study that may affect study results.

Other illness

• Patient life expectancy \<1 year (terminal illness).
• Patient with history of allergic reaction or intolerance to any material used in the study devices or to any of the antithrombotic agents required post-procedure.
• Patient with active systemic infection.

Other

• (MUST NOT MEET ANY EXCLUSION CRITERIA)
• Patient with inability or unwillingness to comply with the study protocol or follow-up requirements.
• Patient pregnant or breastfeeding women.

• (MUST MEET ALL INCLUSION CRITERIA)
• Patient with aged ≥18 years AND;
• Patient have non-valvular atrial (NVAF) with a CHA2DS2-VASc score ≥2, and presented at least one high-bleeding-risk criterion according to the Munich consensus document AND;
• Patient are required to undergo preprocedural TEE / CCTA to confirm the absence of LAA thrombus and to ensure that LAA anatomy is suitable for closure with either device.
• Patient who has been informed of the characteristics of the study and has provided written informed consent..