NCT07263035RecruitingPhase 4
Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure
Source: ClinicalTrials.gov · Last updated 9 Apr 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 1 Apr 2026
- Primary completion date
- 1 Jun 2027
- Lead sponsor
- Lakeland Regional Health Systems, Inc.
- Diseases
- Heart failure
- NCT number
- NCT07263035
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 600
- From 1 Apr 2026 to the primary completion date, 1 Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Exclusion criteria include:
- Admission to the intensive care unit
- Presence of ST-elevated myocardial infarction
- Presence of type 1 non-ST elevated myocardial infarction
- Dyspnea primarily due to non-cardiac cause as judged by the emergency medicine physician or admitting physician
- Use of supplemental oxygen totaling at least 3 L per minute or greater at baseline
- Anuria
- End-stage renal disease per KDIGO criteria
- Dialysis use
Who the study is looking for
- The study will target adults 18 years of age or older admitted to Lakeland Regional Medical Center who:
- Have a primary diagnosis of acute decompensated heart failure, and
- Have at least one of the following signs of hypervolemia:
- Bilateral lower extremity pitting edema
- Jugular venous distension
- Hepatojugular reflex
- Crackles on pulmonary exam, or
- Chest x-ray demonstrating pulmonary edema or pleural effusions
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Lakeland Regional Hospital Coordinator of this site? Confirm its status | Lakeland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.