NCT07263607Not yet recruitingPhase 2
A Multicenter Clinical Trial Evaluating the Efficacy and Safety of Taurine as an Adjunctive Therapy in Multiple Sclerosis
A Multicenter Clinical Study on Taurine Treatment for Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 4 Dec 2025
Brief summary (registry, in English)
This multicenter, randomized, open-label clinical trial aims to evaluate the efficacy and safety of taurine as an adjunctive therapy to standard disease-modifying treatments (DMTs) in patients with multiple sclerosis (MS). The study seeks to determine whether oral taurine can reduce the number and volume of new or enlarging MRI lesions, decrease relapse rates, and slow disability progression as measured by the Expanded Disability Status Scale (EDSS). It will also explore the effects of taurine on gut microbiota composition, serum neurodegeneration biomarkers (GFAP and NfL), and cognitive function assessed by MMSE and MoCA. Approximately 80 eligible participants will be enrolled and randomly assigned to either continue standard DMT therapy or receive taurine supplementation in addition to DMTs. The treatment duration will be 24 months, with follow-up visits every 3 months for clinical assessment, blood and stool sample collection, and MRI scans every 6 months. This study aims to provide new clinical evidence supporting taurine as a safe and potentially beneficial adjunctive therapy for multiple sclerosis.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 80 (estimated)
- First submitted
- 24 Nov 2025
- Start date
- 1 Jan 2026
- Primary completion date
- Jul 2029
- Lead sponsor
- Sichuan Academy of Medical Sciences
- Diseases
- Multiple sclerosis
- NCT number
- NCT07263607
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 80
- From 1 Jan 2026 to the primary completion date, Jul 2029
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- 1\. Patients with known hypersensitivity to taurine or any of its components
Other
- 2\. Women who are pregnant or breastfeeding
- 3\. Patients currently participating in other clinical trials
- 4\. Patients who refuse to participate in the relevant clinical study
Who the study is looking for
- 1.Age and Gender: Male or female participants aged 18 to 65 years.
- 2.Diagnosis: Patients diagnosed with multiple sclerosis (MS) according to the 2017 revised McDonald criteria.
- 3.Treatment Background: Patients receiving stable disease-modifying therapy (DMT) prior to enrollment.
- 4\. EDSS score between 1.0 and 5.5 at screening.
- 5\. Compliance: Ability and willingness to comply with all study procedures, follow-up visits, and study medication requirements.
- 6.Informed Consent: Participants must provide written informed consent before any study-specific procedures are performed.
- 7 Female participants must be non-pregnant and non-lactating, or, if of childbearing potential, must agree to use effective contraception during the study
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.