NCT07264452Recruiting
Comparison of the Efficacy of Accelerated Intermittent Theta Burst Stimulation and Accelerated Continuous Theta Burst Stimulation in Patients With Treatment-Resistant Depression
Source: ClinicalTrials.gov · Last updated 4 Dec 2025
Brief summary (registry, in English)
In recent years, research on the effectiveness of transcranial magnetic stimulation (TMS) in patients with treatment-resistant depression (RTD) has been steadily increasing. The aim of this study was to examine the effectiveness of accelerated unilateral application of two different forms of theta burst stimulation (TBU), a variation of repetitive TMU (rTMS)-intermittent TBU (iTBU) and continuous TBU (cTBU)-in TDD patients. The study aimed to compare the advantages of iTBU and cTBU protocols on depression, suicidal thoughts, anxiety levels, sleep disturbances, cognitive performance, and overall functioning following a two-week intensive treatment period and a 12-week follow-up period.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 21 Nov 2025
- Start date
- 15 Nov 2025
- Primary completion date
- 15 Nov 2026
- Lead sponsor
- Ataturk University
- Diseases
- Depression
- NCT number
- NCT07264452
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Nov 2025 to the primary completion date, 15 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Having a foreign body such as a pacemaker, intracranial implant that can magnetically interact
Other illness
- Diagnosed with a neurological or metabolic disease that affects cognitive functions (Systemic diseases such as diabetes mellitus, cardiovascular disease, cerebrovascular disease, chronic renal failure, Parkinson's disease, multiple sclerosis, polyneuropathy, inflammatory rheumatologic disease and malignancies)
- Unstable or acute medical conditions
- Having a primary psychiatric disorder other than major depressive disorder
Other
- Hearing and visual impairments that prevent communication
- Pregnancy or breastfeeding
- Being diagnosed with severe MDD with psychotic features
Who the study is looking for
- 18 to 65 years old
- Patients diagnosed with Major Depressive Disorder according to DSM 5 and the severity of their illness
- Scoring 7 points or more on the Maudsley staging method
- Having depression unresponsive to 2 different antidepressants
- No clinical mental retardation
- Agree to participate in the study
- Hamilton Depression Rating Scale-17 \[HDRS\] score of 20 or higher
- Montgomery Asberg Depression Rating Scale \[MADRS\] score of 20 or above
- Being right hand dominant
- Having used the same antidepressant at the same dose for the last 4 weeks
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Atatürk University Coordinator of this site? Confirm its status | Erzurum | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.