NCT07265271Recruiting
Project for Multi-Omics-Based Early Detection of Hepatocellular Carcinoma (PROMETHEA Study)
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
Hepatocellular carcinoma (HCC) is often diagnosed at an advanced stage, and early detection is critical for improving patient outcomes. Despite this, reliable non-invasive biomarkers for early-stage HCC are limited. This study seeks to develop a multi-omics-based liquid biopsy assay, especially focusing on ncRNAs (e.g. tsRNA, miRNA, circRNA, lncRNA, etc.) for accurate detection of early-stage HCC.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 600 (estimated)
- First submitted
- 24 Nov 2025
- Start date
- 15 Jan 2025
- Primary completion date
- 18 Jun 2028
- Lead sponsor
- City of Hope Medical Center
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07265271
What you commit to
- Study type: Observational
- Planned participants: 600
- From 15 Jan 2025 to the primary completion date, 18 Jun 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous liver transplantation
Other illness
- History of other active malignancies within the past 5 years
- Severe systemic infection or inflammatory disease at the time of enrollment
Other
- Lack of or inability to provide informed consent
- Inadequate sample quality or quantity
Who the study is looking for
- Adults aged 18 to 100 years.
- A histologically confirmed diagnosis of hepatocellular carcinoma.
- A clinically diagnosed as chronic liver disease, including chronic hepatitis or liver cirrhosis, without evidence of hepatocellular carcinoma.
- Healthy volunteers without known liver disease or malignancy.
- Received standard diagnostic and staging procedures as per local guidelines
- Availability of blood or other biospecimens.
- Ability to provide written informed consent.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| City of Hope Medical Center Coordinator of this site? Confirm its status | Duarte | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.