NCT07265323Recruiting
Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition
Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition
Source: ClinicalTrials.gov · Last updated 4 Dec 2025
Brief summary (registry, in English)
The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention. The main questions it aims to answer are: Does the intervention improve insulin sensitivity (how the body uses glucose)? Does the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)? What changes occur in brain glucose uptake (FDG-PET)? Participants will: Receive the intervention once a week for 6 months, with each session lasting up to 2 hours Complete cognitive assessments. Adverse events will be assessed throughout the study.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 8 (estimated)
- First submitted
- 18 Nov 2025
- Start date
- Dec 2025
- Primary completion date
- May 2027
- Lead sponsor
- Pennington Biomedical Research Center
- Diseases
- Alzheimer disease
- NCT number
- NCT07265323
What you commit to
- Study type: Interventional
- Planned participants: 8
- From Dec 2025 to the primary completion date, May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- On daily medication for the specific treatment of anxiety including benzodiazepines.
Other illness
- Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).
Other
- An infant, child, or teenager
- A pregnant woman
- A prisoner
Who the study is looking for
- Mini Mental State Examination (MMSE) score \< 25
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Pennington Biomedical Research Center Coordinator of this site? Confirm its status | Baton Rouge | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.