NCT07266935Completed
Posterior Pericardiotomy for Prevention of POAF After Cardiac Surgery: RCT in Yemen
A Prospective, Randomized Controlled Trial Evaluating the Effectiveness of Posterior Pericardiotomy in Preventing Postoperative Atrial Fibrillation Among Yemeni Cardiac Surgical Patients
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
A single-center, randomized controlled trial in Yemen evaluating whether posterior pericardiotomy (PP) reduces postoperative atrial fibrillation (POAF) after open-heart surgery. 210 patients undergoing CABG, aortic valve replacement, ascending aortic surgery, or combined procedures were randomized 1:1 to receive either posterior pericardiotomy (PP group, n = 106) or standard care (control group, n = 104). Outcomes assessed included POAF incidence, pericardial effusion, cardiac tamponade, ICU stay, mechanical ventilation, in-hospital mortality, and re-exploration for bleeding or tamponade.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 210 (actual)
- First submitted
- 26 Sept 2025
- Start date
- 1 Jan 2022
- Primary completion date
- 30 Jun 2024
- Lead sponsor
- Taiz University - Faculty of Medicine
- Diseases
- Atrial fibrillation
- NCT number
- NCT07266935
What you commit to
- Study type: Interventional
- Participants enrolled: 210
- From 1 Jan 2022 to the primary completion date, 30 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous cardiac or thoracic surgery
- Mitral or tricuspid valve surgery (excluded due to distinct pathophysiology and POAF risk)
Other illness
- Preoperative atrial fibrillation or other rhythm disorders
Lab values
- Renal failure with plasma creatinine \>2.0 mg/dL
Other
- Left-sided pleural adhesions
- Hyperthyroidism
- Off-pump CABG
- Refusal to participate
Who the study is looking for
- Age ≥18 years.
- Elective open-heart surgery:
- Coronary artery bypass grafting (CABG) Aortic valve replacement Ascending aortic surgery Combined procedures (e.g., CABG + valve replacement)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cardiovascular & Kidney Transplantation Centre, Taiz University, Taiz, Yemen Coordinator of this site? Confirm its status | Taiz | Yemen | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.