NCT07267312Completed
Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome
Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome: A Tertiary Cardiac Center Registry
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
This study aimed to explore the relationship between familial hypercholesterolemia and premature coronary artery disease, particularly in the context of acute coronary syndrome, by reviewing current evidence and highlighting the need for improved screening and aggressive lipid-lowering strategies in high-risk populations.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 2000 (actual)
- First submitted
- 25 Nov 2025
- Start date
- 1 Dec 2021
- Primary completion date
- 27 Mar 2025
- Lead sponsor
- Cairo University
- Diseases
- Coronary artery disease
- NCT number
- NCT07267312
What you commit to
- Study type: Observational
- Participants enrolled: 2000
- From 1 Dec 2021 to the primary completion date, 27 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous congenital or structural heart disease, cardiomyopathy, or significant valvular heart disease unrelated to CAD.
Other illness
- Secondary causes of dyslipidemia, including uncontrolled hypothyroidism, nephrotic syndrome, chronic liver disease, or use of lipid-altering medications (other than statins) before presentation.
- Severe chronic kidney disease (estimated glomerular filtration rate \<30 mL/min/1.73 m²) or patients on dialysis.
- Autoimmune, inflammatory, or systemic diseases known to influence vascular inflammation or lipid metabolism.
- Malignancy or life expectancy \<6 months due to non-cardiac causes.
Lab values
- Incomplete medical records or missing essential laboratory, imaging, or demographic data.
Other
- Pregnant or lactating women.
- Non-Saudi patients (focusing on Saudi population in southern region).
Who the study is looking for
- Age ≥18 years at the time of presentation.
- Both sexes.
- Confirmed diagnosis of coronary artery disease (CAD), established by clinical presentation, electrocardiographic findings, elevated cardiac biomarkers, and/or angiographic evidence of ≥50% luminal stenosis in at least one major coronary artery.
- Hospital admission to the participating cardiology department between \[insert study period, e.g., January 2020 and December 2024\] for acute coronary syndrome (ACS), including unstable angina, non-ST-elevation myocardial infarction (NSTEMI), or ST-elevation myocardial infarction (STEMI).
- Availability of complete clinical, laboratory, and echocardiographic data necessary for classification and analysis.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cairo University Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.