NCT07267325Not yet recruiting
Bone Health in Postmenopausal Women: The Effect of Exercise With or Without Medication for Osteoporosis
The Effect of Exercise With or Without Antiresorptive Therapy, on Bone Properties in Postmenopausal Women With Low BMD - Randomised Controlled Unilateral Intervention Trial
Source: ClinicalTrials.gov · Last updated 5 Dec 2025
Brief summary (registry, in English)
Osteoporosis is a systemic bone disorder characterised by a reduced bone mass and structural deterioration, increasing the risk of fragility fractures, particularly in women post-menopause. Bone mass and structure can be assessed by scans. Antiresorptive medications are commonly prescribed to reduce bone resorption, preventing further bone loss and thus reducing the possibility of fracture. Exercise can also benefit bone mass and structure but current evidence do not show whether exercise is more, or less, effective in combination with antiresorptive medication. This study will compare the effect of a brief, home-based exercise programme on bone mineral and structural properties in women taking/ not taking antiresorptive medication.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 110 (estimated)
- First submitted
- 14 Nov 2025
- Start date
- 1 Jan 2026
- Primary completion date
- Sept 2027
- Lead sponsor
- Loughborough University
- Diseases
- Osteoporosis
- NCT number
- NCT07267325
What you commit to
- Study type: Interventional
- Planned participants: 110
- From 1 Jan 2026 to the primary completion date, Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any medical condition, surgery, or injuries that contraindicate exercises including lower limb or back pain, knee or hip osteoarthritis.
Other
- Body mass index (BMI) \>35 kg/m2
- Vertebral fracture or multiple low trauma fractures (recent expert consensus recommends lower impact exercise for these groups)
- Replacement of hip joint(s)
Who the study is looking for
- Women aged 55-75 years old
- \>4y since menopause/hysterectomy/oophorectomy.
- Baseline femoral neck or lumber spine BMD T-score between -1 and -3.
- Able to complete the hopping exercises.
- Have no regular involvement for more than once/week in:
- Strength, powerlifting or high load resistance exercise.
- High to moderate impact exercise that known to involve ground reaction forces 2 to 4 times greater than body weight (e.g. Jogging).
- Treatment group: taking antiresorptive treatment for osteoporosis continuously for at least 12 months, and who intend to continue this medication for the rest of the study.
- Control group: not taking any medication affecting bone and no intention to commence such medication for the rest of the study.
Age in the registry: 55 years to 75 years · Sex: Female · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Loughborough University Coordinator of this site? Confirm its status | Loughborough | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.