NCT07269223Completed
Oral Vitamin D3 Effect on Inflammatory Biomarkers in Ulcerative Colitis Patients
Effect Of Oral Vitamin D3 Supplementation On Inflammatory Biomarkers In Patients With Ulcerative Colitis
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
This randomized controlled trial aims to evaluate the effect of oral vitamin D3 supplementation on inflammatory biomarkers and disease activity in Pakistani patients with moderate ulcerative colitis. Sixty patients will be randomized to receive either standard treatment alone/Placebo or standard treatment plus vitamin D3 (50,000 IU fortnightly) for 12 weeks. Primary outcomes include changes in blood (CRP, ESR, IL-6) and fecal (calprotectin) inflammatory biomarkers, and disease activity assessed by the partial Mayo score. Secondary outcomes include vitamin D status, dietary intake, and quality of life. The study will provide insights into the immune-modulating and anti-inflammatory role of vitamin D3 as an adjunct therapy in ulcerative colitis.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 25 Nov 2025
- Start date
- 2 Dec 2025
- Primary completion date
- 15 Feb 2026
- Lead sponsor
- University of Veterinary and Animal Sciences, Lahore - Pakistan
- Diseases
- Ulcerative colitis
- NCT number
- NCT07269223
What you commit to
- Study type: Interventional
- Participants enrolled: 60
- From 2 Dec 2025 to the primary completion date, 15 Feb 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Changes in the type and dosage of the drug during the study
Other illness
- Patients suffering from Crohn's disease or any known autoimmune disease
- Patients with known kidney disease
- Patients with known liver disease
Other
- Patients with mild and severe ulcerative colitis
- Pregnant and lactating women
Who the study is looking for
- • All patients diagnosed previously by standard clinical i.e Truelove and Witts and endoscopic/ colonoscopic criteria
- Patients with moderate ulcerative colitis will be included
- Both male and female patients will be included in the study
- No change in the type and dosage of their medicine over the past month
- Patient with severe vitamin D deficiency (\< 10 ng/mL) after screening
- Patients who will provide written informed consent
- Age: 20-40 year
Age in the registry: 20 years to 40 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Veterinary & Animal Sciences, Lahore Coordinator of this site? Confirm its status | Lahore | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.