Efficacy and Safety of Home-based Structured Physical Exercise in Patients With Acute Ischemic Stroke

Prior treatment

• Concurrent osteoarthritis, fractures, deep vein thrombosis, unstable angina, severe heart diseases, respiratory diseases, or amputation that may theoretically make it difficult for participants to complete the physical exercise or ambulation;
• Concurrent movement disorders such as Parkinson's disease or Parkinsonism;
• Currently participating in another drug or device study;

Other illness

• Stroke progression within the past 3 days (defined as an increase in NIHSS score of ≥4 points or an increase in any single item of ≥2 points);
• Unable to comply with the study procedures or follow-up due to psychiatric, cognitive, or emotional disorders;
• Other conditions considered by investigators to be unsuitable for inclusion.

Other

• Patients who have engaged in regular aerobic physical activity within the past 6 months, defined as more than 150 minutes of moderate-intensity aerobic physical activity; or more than 75 minutes of vigorous-intensity aerobic physical activity; or an equivalent combination of moderate- and vigorous-intensity activity throughout the week;
• Known pregnancy or lactation, or a positive pregnancy test;
• Life expectancy less than 1 year;
• Unable to communicate using a smartphone;

• Age 18 years or greater, male or female;
• Acute ischemic stroke onset within 14 days;
• modified Rankin scale (mRS) score ≤ 3;
• Signed informed consent from the patients or the legally authorized representatives.