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NCT07271186RecruitingPhase 2

Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease

A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ALN-ANG3 in Participants With Diabetic Kidney Disease

Source: ClinicalTrials.gov · Last updated 27 Oct 2026

Brief summary (registry, in English)

This study is researching an experimental drug called ALN-ANG3 (called "study drug"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
195 (estimated)
First submitted
21 Nov 2025
Start date
9 Jan 2026
Primary completion date
13 Oct 2028
Lead sponsor
Regeneron Pharmaceuticals
NCT number
NCT07271186
EU CT number
2026-527519-41-00

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 195
  • From 9 Jan 2026 to the primary completion date, 13 Oct 2028
  • 59 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Renal disease that required treatment with systemic immunosuppressive therapy (prior or current), or a history of end-stage kidney disease requiring treatment with chronic dialysis or kidney transplantation

Other illness

  • Known medical history or clinical evidence indicative of non-diabetic renal disease

Other

  • Medically unstable as assessed by the investigator or hospitalization (ie, \>24 hours) within 30 days of the screening visit
    • NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

Who the study is looking for

  • Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management
  • Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening
  • eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening
  • Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening

Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (59)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
University of Michigan
Coordinator of this site? Confirm its status
Ann ArborUnited StatesRecruiting
Arlington Nephrology, PLLC.
Coordinator of this site? Confirm its status
ArlingtonUnited StatesRecruiting
Northeast Clinical Research Center
Coordinator of this site? Confirm its status
BethlehemUnited StatesRecruiting
Velocity Clinical Research
Coordinator of this site? Confirm its status
BinghamtonUnited StatesRecruiting
Southeast Renal Research Institute
Coordinator of this site? Confirm its status
ChattanoogaUnited StatesWithdrawn
Research by Design, LLC - Internal Medicine
Coordinator of this site? Confirm its status
ChicagoUnited StatesRecruiting
Elixia MNA
Coordinator of this site? Confirm its status
City of Saint PetersUnited StatesRecruiting
M3 Wake Research Dallas - Internal Medicine
Coordinator of this site? Confirm its status
DallasUnited StatesRecruiting
Revival Research Institute, LLC
Coordinator of this site? Confirm its status
DallasUnited StatesRecruiting
Epic Medical Research LLC
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DeSotoUnited StatesRecruiting
D&H Doral Research Center
Coordinator of this site? Confirm its status
DoralUnited StatesRecruiting
El Paso Kidney Specialists-Davita Clinical Research
Coordinator of this site? Confirm its status
El PasoUnited StatesRecruiting
Eastern Nephrology Associates - Greenville West
Coordinator of this site? Confirm its status
GreenvilleUnited StatesRecruiting
AGA Clinical Trials
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HialeahUnited StatesRecruiting
Convenient Medical Center
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HialeahUnited StatesRecruiting
Elixia Hollywood
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HollywoodUnited StatesRecruiting
Clinical Trial Network LLC
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HoustonUnited StatesRecruiting
Juno Research, LLC
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HoustonUnited StatesRecruiting
Prolato Research LLC
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HoustonUnited StatesRecruiting
AME Clinical Research
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Huntington BeachUnited StatesRecruiting
Apogee Clinical Research, LLC
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HuntsvilleUnited StatesRecruiting
Clinical Research Consultants, LLC
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Kansas CityUnited StatesRecruiting
R&H Clinical Research, Inc.
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KatyUnited StatesRecruiting
Gulf Coast Clinical Research
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KatyUnited StatesRecruiting
DaVita Clinical Research
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Las VegasUnited StatesRecruiting
Applied Research Center of Arkansas
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Little RockUnited StatesRecruiting
D&H Pompano Research Center
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MargateUnited StatesRecruiting
Sunbeam Clinical Research
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McKinneyUnited StatesRecruiting
Regenerate Primary Medical Research, LLC
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MiamiUnited StatesRecruiting
D&H National Research Centers, Inc
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MiamiUnited StatesRecruiting
LCC Medical Research Institute
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MiamiUnited StatesRecruiting
Ocean Blue Medical Research Center - Internal Medicine
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Miami SpringsUnited StatesRecruiting
Innovia Research Center
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MiramarUnited StatesRecruiting
IMA Clinical Research
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MonroeUnited StatesRecruiting
Eastern Nephrology Associates - New Bern
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New BernUnited StatesRecruiting
Yale University
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New HavenUnited StatesRecruiting
Amicis Research Center
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NorthridgeUnited StatesRecruiting
University of Nebraska Medical Center
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OmahaUnited StatesRecruiting
Central Florida Kidney Specialists Oakwater
Coordinator of this site? Confirm its status
OrlandoUnited StatesRecruiting
FOMAT - Vista del Mar Medical Group
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OxnardUnited StatesRecruiting
Bolanos Clinical Research
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Pembroke PinesUnited StatesRecruiting
Elixia Michigan Kidney Consultants
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PontiacUnited StatesRecruiting
Progressive Medical Research
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Port OrangeUnited StatesRecruiting
CDC Research Institute
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Port Saint LucieUnited StatesRecruiting
Central Coast Nephrology
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SalinasUnited StatesWithdrawn
Clinical Advancement Center
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San AntonioUnited StatesRecruiting
University of Texas Health - San Antonio
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San AntonioUnited StatesRecruiting
North America Research Institute
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San DimasUnited StatesRecruiting
Amicis Research Center
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Santa ClaritaUnited StatesRecruiting
Privia Medical Group of Georgia, LLC
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SavannahUnited StatesRecruiting
Providence Medical Research Center
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SpokaneUnited StatesRecruiting
D&H Tamarac Research Center
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TamaracUnited StatesRecruiting
Valiance Clinical Research
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TarzanaUnited StatesRecruiting
CHEAR Center LLC
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The BronxUnited StatesRecruiting
Amicis Research Center
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ValenciaUnited StatesRecruiting
National Institute of Clinical Research, Inc
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VictorvilleUnited StatesRecruiting
Suburban Research Associates
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West ChesterUnited StatesRecruiting
Metabolic Research Institute
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West Palm BeachUnited StatesRecruiting
Brookview Hills Research Associates, LLC
Coordinator of this site? Confirm its status
Winston-SalemUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.