NCT07271186RecruitingPhase 2
Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease
A Phase 2 Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamic Effects of ALN-ANG3 in Participants With Diabetic Kidney Disease
Source: ClinicalTrials.gov · Last updated 27 Oct 2026
Brief summary (registry, in English)
This study is researching an experimental drug called ALN-ANG3 (called "study drug"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 195 (estimated)
- First submitted
- 21 Nov 2025
- Start date
- 9 Jan 2026
- Primary completion date
- 13 Oct 2028
- Lead sponsor
- Regeneron Pharmaceuticals
- Diseases
- Chronic kidney disease, Type 2 diabetes
- NCT number
- NCT07271186
- EU CT number
- 2026-527519-41-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 195
- From 9 Jan 2026 to the primary completion date, 13 Oct 2028
- 59 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Renal disease that required treatment with systemic immunosuppressive therapy (prior or current), or a history of end-stage kidney disease requiring treatment with chronic dialysis or kidney transplantation
Other illness
- Known medical history or clinical evidence indicative of non-diabetic renal disease
Other
- Medically unstable as assessed by the investigator or hospitalization (ie, \>24 hours) within 30 days of the screening visit
- NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply
Who the study is looking for
- Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management
- Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening
- eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening
- Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (59)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Michigan Coordinator of this site? Confirm its status | Ann Arbor | United States | Recruiting |
| Arlington Nephrology, PLLC. Coordinator of this site? Confirm its status | Arlington | United States | Recruiting |
| Northeast Clinical Research Center Coordinator of this site? Confirm its status | Bethlehem | United States | Recruiting |
| Velocity Clinical Research Coordinator of this site? Confirm its status | Binghamton | United States | Recruiting |
| Southeast Renal Research Institute Coordinator of this site? Confirm its status | Chattanooga | United States | Withdrawn |
| Research by Design, LLC - Internal Medicine Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Elixia MNA Coordinator of this site? Confirm its status | City of Saint Peters | United States | Recruiting |
| M3 Wake Research Dallas - Internal Medicine Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Revival Research Institute, LLC Coordinator of this site? Confirm its status | Dallas | United States | Recruiting |
| Epic Medical Research LLC Coordinator of this site? Confirm its status | DeSoto | United States | Recruiting |
| D&H Doral Research Center Coordinator of this site? Confirm its status | Doral | United States | Recruiting |
| El Paso Kidney Specialists-Davita Clinical Research Coordinator of this site? Confirm its status | El Paso | United States | Recruiting |
| Eastern Nephrology Associates - Greenville West Coordinator of this site? Confirm its status | Greenville | United States | Recruiting |
| AGA Clinical Trials Coordinator of this site? Confirm its status | Hialeah | United States | Recruiting |
| Convenient Medical Center Coordinator of this site? Confirm its status | Hialeah | United States | Recruiting |
| Elixia Hollywood Coordinator of this site? Confirm its status | Hollywood | United States | Recruiting |
| Clinical Trial Network LLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Juno Research, LLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Prolato Research LLC Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| AME Clinical Research Coordinator of this site? Confirm its status | Huntington Beach | United States | Recruiting |
| Apogee Clinical Research, LLC Coordinator of this site? Confirm its status | Huntsville | United States | Recruiting |
| Clinical Research Consultants, LLC Coordinator of this site? Confirm its status | Kansas City | United States | Recruiting |
| R&H Clinical Research, Inc. Coordinator of this site? Confirm its status | Katy | United States | Recruiting |
| Gulf Coast Clinical Research Coordinator of this site? Confirm its status | Katy | United States | Recruiting |
| DaVita Clinical Research Coordinator of this site? Confirm its status | Las Vegas | United States | Recruiting |
| Applied Research Center of Arkansas Coordinator of this site? Confirm its status | Little Rock | United States | Recruiting |
| D&H Pompano Research Center Coordinator of this site? Confirm its status | Margate | United States | Recruiting |
| Sunbeam Clinical Research Coordinator of this site? Confirm its status | McKinney | United States | Recruiting |
| Regenerate Primary Medical Research, LLC Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| D&H National Research Centers, Inc Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| LCC Medical Research Institute Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Ocean Blue Medical Research Center - Internal Medicine Coordinator of this site? Confirm its status | Miami Springs | United States | Recruiting |
| Innovia Research Center Coordinator of this site? Confirm its status | Miramar | United States | Recruiting |
| IMA Clinical Research Coordinator of this site? Confirm its status | Monroe | United States | Recruiting |
| Eastern Nephrology Associates - New Bern Coordinator of this site? Confirm its status | New Bern | United States | Recruiting |
| Yale University Coordinator of this site? Confirm its status | New Haven | United States | Recruiting |
| Amicis Research Center Coordinator of this site? Confirm its status | Northridge | United States | Recruiting |
| University of Nebraska Medical Center Coordinator of this site? Confirm its status | Omaha | United States | Recruiting |
| Central Florida Kidney Specialists Oakwater Coordinator of this site? Confirm its status | Orlando | United States | Recruiting |
| FOMAT - Vista del Mar Medical Group Coordinator of this site? Confirm its status | Oxnard | United States | Recruiting |
| Bolanos Clinical Research Coordinator of this site? Confirm its status | Pembroke Pines | United States | Recruiting |
| Elixia Michigan Kidney Consultants Coordinator of this site? Confirm its status | Pontiac | United States | Recruiting |
| Progressive Medical Research Coordinator of this site? Confirm its status | Port Orange | United States | Recruiting |
| CDC Research Institute Coordinator of this site? Confirm its status | Port Saint Lucie | United States | Recruiting |
| Central Coast Nephrology Coordinator of this site? Confirm its status | Salinas | United States | Withdrawn |
| Clinical Advancement Center Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| University of Texas Health - San Antonio Coordinator of this site? Confirm its status | San Antonio | United States | Recruiting |
| North America Research Institute Coordinator of this site? Confirm its status | San Dimas | United States | Recruiting |
| Amicis Research Center Coordinator of this site? Confirm its status | Santa Clarita | United States | Recruiting |
| Privia Medical Group of Georgia, LLC Coordinator of this site? Confirm its status | Savannah | United States | Recruiting |
| Providence Medical Research Center Coordinator of this site? Confirm its status | Spokane | United States | Recruiting |
| D&H Tamarac Research Center Coordinator of this site? Confirm its status | Tamarac | United States | Recruiting |
| Valiance Clinical Research Coordinator of this site? Confirm its status | Tarzana | United States | Recruiting |
| CHEAR Center LLC Coordinator of this site? Confirm its status | The Bronx | United States | Recruiting |
| Amicis Research Center Coordinator of this site? Confirm its status | Valencia | United States | Recruiting |
| National Institute of Clinical Research, Inc Coordinator of this site? Confirm its status | Victorville | United States | Recruiting |
| Suburban Research Associates Coordinator of this site? Confirm its status | West Chester | United States | Recruiting |
| Metabolic Research Institute Coordinator of this site? Confirm its status | West Palm Beach | United States | Recruiting |
| Brookview Hills Research Associates, LLC Coordinator of this site? Confirm its status | Winston-Salem | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.