NCT07271225Recruiting
Safety and Efficacy of Ear Acupuncture for Antituberculosis Drug-Related Nausea and Vomiting
Effectiveness and Safety of Auricular Acupuncture for Nausea and Vomiting Side Effects Induced by Anti-Tuberculosis Drugs in Pulmonary TB Patients
Source: ClinicalTrials.gov · Last updated 9 Dec 2025
Brief summary (registry, in English)
This study will look at whether press-needle ear acupuncture can help lower nausea and vomiting caused by antituberculosis medicines in people with pulmonary tuberculosis. Nausea and vomiting are common side effects of tuberculosis treatment, and they can make people stop taking their medicines When treatment is stopped too early, tuberculosis may not be cured and may become resistant to medicines. Participants in this study will have nausea and vomiting related to their tuberculosis treatment. They will be randomly assigned to one of two groups. One group will receive press-needle ear acupuncture. The other group will receive a placebo version that looks similar but does not stimulate acupuncture points Researchers will check nausea and vomiting scores before treatment, during treatment, and after treatment to see whether press-needle acupuncture works better than placebo and whether it is safe. Press-needle acupuncture may help reduce nausea and vomiting by affecting nerves and lowering certain chemicals that trigger these symptoms, and it has minimal side effects If this method is proven helpful and safe, it may give patients a comfortable and low-risk way to manage nausea and vomiting during tuberculosis treatment
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 58 (estimated)
- First submitted
- 27 Nov 2025
- Start date
- 5 Nov 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Universitas Indonesia
- Diseases
- Tuberculosis
- NCT number
- NCT07271225
What you commit to
- Study type: Interventional
- Planned participants: 58
- From 5 Nov 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participants who experience nausea and vomiting prior to antituberculosis treatment (including comorbidities that may cause nausea and vomiting, such as renal failure and liver disorders)
- Participants with drug-resistant tuberculosis (DR-TB) receiving long-term or individualized treatment regimens
- Participants who have received acupuncture therapy within the last 2 weeks
- Participants with a history of hypersensitivity reactions to previous acupuncture treatment
Lab values
- Participants with diabetes mellitus and a random blood glucose level \> 200 mg/dL
- Participants with coagulation disorders (platelet count \< 50,000/µL)
Other
- Presence of skin lesions at the site where press needles (PN) will be applied
- Participants with unstable hemodynamic status
Who the study is looking for
- Participants are individuals diagnosed with drug-sensitive tuberculosis or drug-resistant tuberculosis receiving short-term treatment regimens (BPaL/BPaLM)
- Participants are aged 17 years or older.
- Participants experience nausea and vomiting after taking antituberculosis drugs.
- Participants are willing to comply with the study schedule until completion and provide written informed consent.
Age in the registry: 17 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| RSUP Persahabatan Coordinator of this site? Confirm its status | Jakarta | Indonesia | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.