NCT07271771RecruitingPhase 4
The effect of denosumab on muscle and strength and insulin sensitivity
Source: EU CTIS (euclinicaltrials.eu) · Last updated 20 May 2026
Brief summary (registry, in English)
Randomized, placebo controlled prospective trial evaluating the effect of denosumab on insulin sensitivity and muscle strength.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 4
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 5 Jan 2024
- Start date
- 21 May 2024
- Lead sponsor
- Region Midtjylland
- Diseases
- Osteoporosis
- EU CT number
- 2024-510637-18-00
What you commit to
- Study type: Interventional · Phase 4
- Planned participants: 40
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of EU CTIS (euclinicaltrials.eu). It describes the study, not your situation.
Who cannot take part
Copied verbatim from EU CTIS (euclinicaltrials.eu) and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other antidiabetic medication than metformin
- Ongoing treatment with systemic glucocorticoids
Other illness
- Metabolic bone disease (for example osteogenesis imperfecta, Paget's disease of bone, hyperparathyroidism)
- Active cancer within the last 5 years with the exception of basal cell skin cancer
Lab values
- Treatment affecting bone, calcium metabolism or muscle
- Estimated glomerular filtration rate (eGFR) ≤ 35 mL/min
Other
- Treatment for osteoporosis at any time
- Unable to read and understand Danish
- Immobility
- Low-energy vertebral fractures at any time
- Low-energy hip fracture at any time
Who the study is looking for
- Postmenopausal women (postmenopausal for at least two years)
- Age ≥ 40 years
- BMD T-score ≥ -2.0 (lumbar spine, total hip or femoral neck)
- At least 2 lumbar vertebrae that can be evaluated by dual-energy x-ray absorptiometry (DXA)
- Diabetes Mellitus type 2
- Treatment with metformin as monotherapy
Age in the registry: 18 years to 64 years · Sex: Female · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Region Midtjylland Coordinator of this site? Confirm its status | Aarhus N | Denmark | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.