NCT07273058Recruiting
Effect of HIIT on Post-Stroke Fatigue
Effect of High-Intensity Interval Training Intervention on Post-Stroke Fatigue in Chronic Stroke Survivors: A Pilot Randomized Clinical Trial
Source: ClinicalTrials.gov · Last updated 9 Dec 2025
Brief summary (registry, in English)
This study aims to investigate the effect of high-intensity interval training (HIIT) on fatigue severity among individuals with chronic stroke. Participants will be randomly assigned to the HIIT group, the moderate-intensity continuous training (MICT) group, or the stretching group (active control). Each group will participate in supervised exercise sessions three times per week over a 12-week period, totaling 36 sessions. Outcome assessments will be conducted at baseline, mid-intervention (week 6), post-intervention (week 12), and follow-up (week 20). The primary outcome will be fatigue severity. Secondary outcomes will include inflammatory biomarkers and additional health-related indicators.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 16 Sept 2025
- Start date
- 15 Oct 2025
- Primary completion date
- 1 Oct 2027
- Lead sponsor
- The Hong Kong Polytechnic University
- Diseases
- Stroke
- NCT number
- NCT07273058
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 15 Oct 2025 to the primary completion date, 1 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- signs or symptoms indicative of significant cardiovascular, pulmonary, or metabolic disease(s) during the previous 3 months;
- current or previous use of drugs intended to resolve post-stroke fatigue;
Other illness
- other neurological conditions;
- a medical diagnosis of significant cardiovascular, pulmonary, or metabolic disease(s);
- active engagement in other stroke rehabilitation trials.
Other
- An FSS score of \< 4 (20);
- other musculoskeletal comorbidities that would prevent safe participation in exercises;
- severe lower limb spasticity (Ashworth Scale score ≥ 3);
- Botulinum toxin use in the affected lower limb within the past six months;
Who the study is looking for
- Age of 40-80 years;
- a history of ischemic stroke resulting in unilateral limb impairment 6-60 months prior to consent to participate in the pilot trial;
- a stable medical condition;
- a subjective feeling of fatigue, defined as a period of apparent fatigue, decreased energy, increased need for rest, or fatigue out of proportion to physical activity for at least 2 weeks during the past month;
- ability to communicate with the investigators and lack of significant cognitive deficits;
- able to walk for 10 meters with or without a walking aid.
Age in the registry: 40 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The Hong Kong Polytechnic University Coordinator of this site? Confirm its status | Kowloon | Hong Kong SAR China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.