NCT07274124Recruiting
Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis
Comparison of the Effects of Pain Neuroscience Education and Vagus Nerve Stimulation on Recovery in Individuals With Rheumatoid Arthritis
Source: ClinicalTrials.gov · Last updated 9 Oct 2026
Brief summary (registry, in English)
In the context of this randomized controlled study, patients who are diagnosed with Rheumatoid arthritis in Cerrahpaşa Faculty of Medicine Hospital, will be taken into a rehabilitation program by a qualified physiotherapist to improve their pain, pain perception, inflammatory markers and quality of life, with one of the pain neuroscience education, vagal nerve stimulation and traditional exercise interventions. The results of each intervention method will be analyzed and compared at the end of the 8 weeks study protocol.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 18 Feb 2026
- Primary completion date
- 31 May 2027
- Lead sponsor
- Medipol University
- Diseases
- Rheumatoid arthritis
- NCT number
- NCT07274124
What you commit to
- Study type: Interventional
- Planned participants: 42
- From 18 Feb 2026 to the primary completion date, 31 May 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients whose medication was changed,
Other illness
- Having a history of surgery within the last year,
- Having any of the cerebrovascular disease, cardiovascular disease, symptomatic coronary artery disease, myocardial infarction, congestive heart failure, or uncontrolled hyper/hypotension,
- History of vagotomy surgery, or having an implanted electrical/neurostimulator device will not be included in the study.
Age
- Individuals under 20 years of age,
Other
- Reporting acute pain or pain from injury,
- Remission in DAS28,
- Having a score of \<24 on the MMSE,
Who the study is looking for
- Individuals who were diagnosed with RA at least one year ago,
- More than score 2.6 in DAS28,
- Ages of 20 and 65,
- Have been experiencing pain for three months or more,
- Score 24 or higher on the Mini Mental State Examination (MMSE), and can follow instructions will be included in the study.
Age in the registry: 20 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cerrahpaşa Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.