NCT07274397Recruiting
Assessment of Early Post-operative Nuclear Imaging in Neurosurgery: a Safety and Feasibility Study in Patients Operated for Glioblastoma
Source: ClinicalTrials.gov · Last updated 8 Jun 2026
Brief summary (registry, in English)
This clinical trial aims to evaluate the feasibility and safety of early post-operative brain PET-MRI imaging in adult patients who have undergone surgery for suspected glioblastoma. The study also seeks to validate specific nuclear imaging parameters for better detection of residual tumor tissue compared to standard gadolinium-enhanced MRI. The main objectives are to determine whether early PET-MRI within 48 hours post-surgery is feasible, to assess potential side effects related to imaging procedures, and to explore if PET parameters such as SUVmax, metabolic volume, and tumor-to-striatum ratio can improve the detection of tumor residue. A total of 15 patients will be included at a single site in France. Participants will undergo PET-MRI using 18F-DOPA and gadolinium, and will be monitored for radiation exposure and possible adverse events up to 24 hours after imaging.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 15 (estimated)
- First submitted
- 16 Sept 2025
- Start date
- 17 Apr 2026
- Primary completion date
- 17 Apr 2027
- Lead sponsor
- Beta Emitting Accurate Monitored Systems
- Diseases
- Glioblastoma
- NCT number
- NCT07274397
What you commit to
- Study type: Interventional
- Planned participants: 15
- From 17 Apr 2026 to the primary completion date, 17 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Any postoperative behavioral disorders or medical condition or symptom impeding the completion of brain imaging
Other
- Postoperative medical dependency impeding the patient transfer to the nuclear medicine department (including, but not limited to, invasive ventilation, need for external ventricular drainage…)
- Postoperative histological diagnosis different from glioblastoma
Who the study is looking for
- First resection for a suspected glioblastoma in the past 72h
- Signed informed consent
- non-inclusion Criteria:
- Deprived of liberty or under legal protection (e.g, guardianship, trusteeship)
- Patients under 18 years old
- Absence of social security cover
- Pregnancy
- Emergency procedure
- Contraindication to brain MRI, including claustrophobia
- Contraindication to radiotracers or gadolinium injection
- Preoperative cognitive impairment impeding patient information
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Henri Mondor - Université Paris-Est Créteil (UPEC) Coordinator of this site? Confirm its status | Créteil | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.