NCT07275177Completed
Effect of Vitamin D on Body Composition and Functionality of Older Adults
Effect of Vitamin D Supplementation on Strength and Muscle Gain in Older Adults With Obesity in Miahuatlán de Porfirio Díaz, in Period 2023-2024
Source: ClinicalTrials.gov · Last updated 10 Dec 2025
Brief summary (registry, in English)
Older adults with obesity often experience a gradual loss of muscle mass and muscle strength, a condition sometimes described as sarcopenic obesity. This combination increases the risk of falls, disability, functional decline, and metabolic complications. Low levels of vitamin D are common in older adults and may contribute to reduced muscle function and poorer physical performance. This study is designed to evaluate whether taking 10,000 International Units (IU) per day of vitamin D3 for 12 weeks can improve muscle strength and muscle mass in older adults with obesity living in southern Mexico. The study will also examine whether vitamin D3 supplementation influences body composition, physical performance, and serum levels of 25-hydroxyvitamin D. Participants will complete assessments at the beginning and at the end of the 12-week period. These assessments include measurements of muscle strength, skeletal muscle mass, body fat percentage, and indicators of physical performance such as the Short Physical Performance Battery (SPPB). Additional measures of body composition and anthropometry, such as body mass index, waist circumference, and related indices, will also be recorded. Blood samples will be analyzed to determine vitamin D status. All participants will receive daily oral vitamin D3 (cholecalciferol) throughout the 12-week intervention. The goal of the study is to understand whether improving vitamin D status can have a positive effect on muscle health and physical function in older adults with obesity. The results from this research may help guide future strategies to prevent or reduce functional decline related to low muscle mass in older adults with obesity, particularly in rural regions of Mexico where vitamin D deficiency is common.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 29 (actual)
- First submitted
- 18 Nov 2025
- Start date
- 9 Jan 2024
- Primary completion date
- 9 Nov 2024
- Lead sponsor
- Universidad Autónoma Benito Juárez de Oaxaca
- Diseases
- Obesity
- NCT number
- NCT07275177
What you commit to
- Study type: Interventional
- Participants enrolled: 29
- From 9 Jan 2024 to the primary completion date, 9 Nov 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of high-dose vitamin D supplementation or medications affecting vitamin D metabolism.
Other illness
- Severe renal or hepatic disease.
- Active cancer treatment.
- Neurological or musculoskeletal conditions that impair mobility or functional testing (e.g., recent fractures, severe osteoarthritis, stroke with major disability).
- Cognitive impairment preventing the understanding of instructions or informed consent.
- Any medical condition that, in the judgment of investigators, would interfere with participation or pose additional risk.
Lab values
- Known diagnosis of hypercalcemia or disorders of calcium metabolism.
Other
- Participation in another clinical trial during the study period.
Who the study is looking for
- Adults aged 60 years or older.
- Diagnosis of obesity (BMI ≥ 30 kg/m²).
- Patients attending the outpatient clinic of IMSS No. 24 in Miahuatlán de Porfirio Díaz, Oaxaca.
- Able to perform physical and functional tests (handgrip, SPPB).
- Capable of providing informed consent.
- Willing to comply with the intervention and attend baseline and 12-week evaluations.
Age in the registry: 60 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Instituto Mexicano del Seguro Social - Unidad de Medicina Familiar 24, Miahuatlán de Porfirio Díaz, Oaxaca, México Coordinator of this site? Confirm its status | Miahuatlán de Porfirio Díaz | Mexico | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.