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NCT07275840RecruitingPhase 2

A Study to Evaluate the Efficacy and Safety of IBI302inSubjects With nAMD

An Open-label, Multicenter, Single-arm Phase II Clinical Study Evaluating the Efficacy and Safety of Intravitreal Injection of IBI302 in Participants With Neovascular Age-related Macular Degeneration

Source: ClinicalTrials.gov · Last updated 8 Jan 2026

Brief summary (registry, in English)

This study is designed for Open-label, multi-center, single-arm Phase II trail to evaluate the efficacy and safety of intravitreal injection of IBI302 in nAMD patients.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
800 (estimated)
First submitted
24 Nov 2025
Start date
5 Dec 2025
Primary completion date
30 Aug 2026
Lead sponsor
Innovent Biologics Technology Limited (Shanghai R&D Center)
NCT number
NCT07275840

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 800
  • From 5 Dec 2025 to the primary completion date, 30 Aug 2026
  • 1 site in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • According to the investigator's judgment, concomitant ocular diseases/systemic diseases of the study eyes at screening or baseline may lead to participants' non-response to the study treatment or confuse the interpretation of the study results;
  • Within 90 days before baseline, the study eye had received anti-VEGF treatment;
  • Within 90 days before baseline, the study eye had received anti-complement treatment;
  • At any time before baseline, the study eye had received IBI302 treatment;

Other illness

  • There is an active intraocular or periocular infection or inflammation in either eye;
  • The non-study eye has severe visual function disorders;
  • Uncontrollable hypertension;

Lab values

  • Glycated hemoglobin (HbA1c) \> 10.0% within 28 days prior to screening;

Other

  • The study eye has uncontrollable glaucoma;
  • Other exclusion criteria set by protocol.

Who the study is looking for

  • Have signed an informed consent form before participating in the research.
  • Male or female individuals aged 50 or above at the time of signing the informed consent form;
  • Active CNV under the macular fovea secondary to nAMD or active CNV involving the macular fovea.
  • At baseline, the BCVA of the study eye was within the range of 19 to 78 ETDRS letters (including both ends).

Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (1)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Shanghai General Hospital
Coordinator of this site? Confirm its status
ShanghaiChinaRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.