NCT07275840RecruitingPhase 2
A Study to Evaluate the Efficacy and Safety of IBI302inSubjects With nAMD
An Open-label, Multicenter, Single-arm Phase II Clinical Study Evaluating the Efficacy and Safety of Intravitreal Injection of IBI302 in Participants With Neovascular Age-related Macular Degeneration
Source: ClinicalTrials.gov · Last updated 8 Jan 2026
Brief summary (registry, in English)
This study is designed for Open-label, multi-center, single-arm Phase II trail to evaluate the efficacy and safety of intravitreal injection of IBI302 in nAMD patients.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 800 (estimated)
- First submitted
- 24 Nov 2025
- Start date
- 5 Dec 2025
- Primary completion date
- 30 Aug 2026
- Lead sponsor
- Innovent Biologics Technology Limited (Shanghai R&D Center)
- Diseases
- Macular degeneration
- NCT number
- NCT07275840
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 800
- From 5 Dec 2025 to the primary completion date, 30 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- According to the investigator's judgment, concomitant ocular diseases/systemic diseases of the study eyes at screening or baseline may lead to participants' non-response to the study treatment or confuse the interpretation of the study results;
- Within 90 days before baseline, the study eye had received anti-VEGF treatment;
- Within 90 days before baseline, the study eye had received anti-complement treatment;
- At any time before baseline, the study eye had received IBI302 treatment;
Other illness
- There is an active intraocular or periocular infection or inflammation in either eye;
- The non-study eye has severe visual function disorders;
- Uncontrollable hypertension;
Lab values
- Glycated hemoglobin (HbA1c) \> 10.0% within 28 days prior to screening;
Other
- The study eye has uncontrollable glaucoma;
- Other exclusion criteria set by protocol.
Who the study is looking for
- Have signed an informed consent form before participating in the research.
- Male or female individuals aged 50 or above at the time of signing the informed consent form;
- Active CNV under the macular fovea secondary to nAMD or active CNV involving the macular fovea.
- At baseline, the BCVA of the study eye was within the range of 19 to 78 ETDRS letters (including both ends).
Age in the registry: 50 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai General Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.