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NCT07277140Not yet recruiting

Impact of Iron Deficiency on Arrhythmic Events and Resting ECG Abnormalities in Patients Hospitalized With Heart Failure

Impact of Iron Deficiency With and Without Anemia on Arrhythmic Events and Resting ECG Abnormalities in Patients Hospitalized With Heart Failure

Source: ClinicalTrials.gov · Last updated 11 Dec 2025

Brief summary (registry, in English)

The relationship between iron deficiency (with or without anemia) and arrhythmic risk or ECG abnormalities in hospitalized HF patients remains poorly characterized. This is particularly relevant in settings where advanced iron therapies (e.g., intravenous iron supplementation) may not be readily available, and where simple clinical and electrocardiographic markers could help identify high-risk patients by evaluating the impact of iron deficiency (with and without anemia) arrhythmic events and resting ECG changes among patients admitted with heart failure. Understanding these associations may offer insights into the arrhythmogenic potential of iron deficiency and support the integration of iron status assessment into routine risk stratification and management of HF patients.

Status (registry)
Not yet recruiting
Study type
Observational
Enrollment
300 (estimated)
First submitted
23 Sept 2025
Start date
Dec 2025
Primary completion date
Jan 2027
Lead sponsor
Assiut University
NCT number
NCT07277140

What you commit to

  • Study type: Observational
  • Planned participants: 300
  • From Dec 2025 to the primary completion date, Jan 2027
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Recent intravenous iron therapy or blood transfusion within the past 3 months.

Other illness

  • End-stage renal disease requiring dialysis.
  • Known anemia due to non-iron-deficiency causes (e.g., hemolytic anemia, active malignancy, etc.).
  • Active systemic infection, chronic inflammatory conditions, or recent chemotherapy.

Lab values

  • Known history of primary electrical disorders (e.g., Brugada syndrome, Long QT syndrome, etc.).

Other

  • Severe electrolyte imbalances (e.g., significant hypo-/hyperkalemia, hypo-/hypermagnesemia).
  • severe valvular lesions

Who the study is looking for

  • Adult patients (≥18 years) admitted to Assiut University Heart Hospital with a clinical diagnosis of heart failure (new-onset or decompensated).
  • Includes all ejection fraction categories (HFrEF, HFmrEF, and HFpEF).
  • Availability of 12-lead ECG, serum iron studies (ferritin, transferrin saturation, serum iron), and routine laboratory tests.
  • Willingness to participate and provide informed consent.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.