NCT07277309Recruiting
Promoting Recovery After Brain Injury Using Focused Ultrasound
Source: ClinicalTrials.gov · Last updated 15 Jun 2026
Brief summary (registry, in English)
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover. In particular, this project aims to (1) determine neurobehavioral responses to low-intensity focused ultrasound (LIFUP) in patients with disorders of consciousness (DoC) following brain injury, (2) determine neurophysiologic (EEG) responses to LIFUP in patients with DoC and (3) identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 20 Nov 2025
- Start date
- May 2026
- Primary completion date
- Jul 2029
- Lead sponsor
- Massachusetts General Hospital
- Diseases
- Stroke
- NCT number
- NCT07277309
What you commit to
- Study type: Interventional
- Planned participants: 36
- From May 2026 to the primary completion date, Jul 2029
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Participation in concurrent therapeutic study
Other illness
- History of neurological disorder other than the brain injury
- Metal implant or other condition precluding MRI
Other
- Manifest continuous spontaneous movement (which would prevent safe/successful MRI)
- Pregnancy
Who the study is looking for
- Brain injury resulting in DoC diagnosis, following international guidelines
- At least 18 years of age
- Legally authorized representative (surrogate) available to consent
Age in the registry: 18 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Massachusetts General Hospital (The General Hospital Corp.) Coordinator of this site? Confirm its status | Boston | United States | Recruiting |
| Spaulding Rehabilitation Hospital Corporation, Inc. Coordinator of this site? Confirm its status | Cambridge | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.