NCT07278388Recruiting
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
Motivated Decision-Making and Performance
Source: ClinicalTrials.gov · Last updated 12 Dec 2025
Brief summary (registry, in English)
This proposal aims to understand the neurobiological mechanisms of fatigue in individuals with Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). This knowledge will eventually provide candidate mechanisms to target with pharmacological intervention and inform rehabilitative care for those individuals suffering from symptoms of fatigue in PASC.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 200 (estimated)
- First submitted
- 19 Nov 2025
- Start date
- 16 Jul 2025
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07278388
What you commit to
- Study type: Interventional
- Planned participants: 200
- From 16 Jul 2025 to the primary completion date, 31 Dec 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had exposure to metal or metal implants, due to the hazardous effects of the magnetic field.
- If on immunomodulatory therapy, they must have been on that therapy for at least 6 months before the start of the study.
- Healthy age- and sex-matched controls for PASC - Exclusion criteria: Participants with a history of any of the following will be excluded from the study:
Other illness
- Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
- Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
- Congestive heart failure.
- Peripheral artery disease with claudication.
- Cancer.
- Pulmonary or renal failure.
- Unstable angina.
- Uncontrolled hypertension (more than 190/110 mmHg).
- Orthopedic or pain conditions.
- Hospitalization due to SARS-CoV-2 infection.
- Neurological disorders including, but not limited to, stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease, or any other neuromuscular disease (self-report).
- Diagnosed history of severe psychiatric diseases such as depression and schizophrenia (self-report).
- Congestive heart failure.
- Peripheral artery disease with claudication.
Other
- Severe aphasia.
Who the study is looking for
- Age 18 to 75 years old.
- Have received a clinical diagnosis of post-acute sequelae of SARS-CoV-2 (PASC)/long COVID syndrome using the criteria specified by Thaweethai, et al., 2023 (JAMA). This symptom checklist provides a score based on the number and severity of symptoms. An individual with a score \>12 is classified as having PASC.
- Currently experiencing Fatigue/Brain Fog as assessed with the Post-COVID symptom checklist and the PedsQL questionnaire.
Age in the registry: 18 years to 75 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Kennedy Krieger Institute Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.