NCT07279402Recruiting
TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%
TRIMPACT: A Prospective Real-World Study of Atezolizumab Monotherapy as First-Line (Stage IV) Treatment in Patients With Non-Small Cell Lung Cancer With PD-L1 Tumor Cell Expression ≥50% and No Targetable Mutations
Source: ClinicalTrials.gov · Last updated 30 Apr 2026
Brief summary (registry, in English)
This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 150 (estimated)
- First submitted
- 1 Dec 2025
- Start date
- 15 Sept 2025
- Primary completion date
- 1 May 2027
- Lead sponsor
- Antalya Training and Research Hospital
- Diseases
- Lung cancer
- NCT number
- NCT07279402
What you commit to
- Study type: Observational
- Planned participants: 150
- From 15 Sept 2025 to the primary completion date, 1 May 2027
- 25 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who are not receiving atezolizumab for the treatment of lung cancer according to standard of care and the approved indication.
Other illness
- Known or suspected hypersensitivity to atezolizumab.
Other
- Pregnant or breastfeeding women.
Who the study is looking for
- Signed informed consent form.
- Diagnosis of stage IV non-small cell lung cancer.
- Male or female patients aged 18 years or older.
- Patients who have been prescribed atezolizumab in accordance with routine clinical practice and the locally approved indication in Türkiye.
- Patients who have received up to 3 cycles of atezolizumab at the screening visit.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (25)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Adana City Hospital Coordinator of this site? Confirm its status | Adana | Turkey (Türkiye) | Recruiting |
| Afyonkarahisar Health Sciences University Hospital Coordinator of this site? Confirm its status | Afyonkarahisar | Turkey (Türkiye) | Recruiting |
| Ankara Atatürk Sanatoryum Training and Research Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Recruiting |
| Ankara Bilkent City Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Not yet recruiting |
| Ankara Oncology Training and Research Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Not yet recruiting |
| Memorial Ankara Hospital Coordinator of this site? Confirm its status | Ankara | Turkey (Türkiye) | Not yet recruiting |
| Antalya Training and Research Hospital Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Recruiting |
| Antalya City Hospital Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Recruiting |
| Adnan Menderes University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Aydin | Turkey (Türkiye) | Recruiting |
| Dicle University Hospital Coordinator of this site? Confirm its status | Diyarbakır | Turkey (Türkiye) | Not yet recruiting |
| Trakya University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Edirne | Turkey (Türkiye) | Recruiting |
| Gaziantep City Hospital Coordinator of this site? Confirm its status | Gaziantep | Turkey (Türkiye) | Recruiting |
| Başakşehir Çam and Sakura City Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
| Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Not yet recruiting |
| İstanbul Medipol Mega Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Not yet recruiting |
| Bahçelievler Memorial Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Not yet recruiting |
| Ümraniye Training and Research Hospital Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Not yet recruiting |
| Dokuz Eylul University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Recruiting |
| Ege University Hospital Coordinator of this site? Confirm its status | Izmir | Turkey (Türkiye) | Recruiting |
| Necmettin Erbakan University Meram Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Konya | Turkey (Türkiye) | Recruiting |
| Mersin University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Mersin | Turkey (Türkiye) | Recruiting |
| Ordu State Hospital Coordinator of this site? Confirm its status | Ordu | Turkey (Türkiye) | Not yet recruiting |
| Sakarya University Faculty of Medicine Hospital Coordinator of this site? Confirm its status | Sakarya | Turkey (Türkiye) | Recruiting |
| Medical Park Samsun Hospital Coordinator of this site? Confirm its status | Samsun | Turkey (Türkiye) | Not yet recruiting |
| Karadeniz Technical University Farabi Hospital Coordinator of this site? Confirm its status | Trabzon | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.