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NCT07279402Recruiting

TRIMPACT: Real-World First-Line Atezolizumab Use in Stage IV NSCLC With PD-L1 ≥50%

TRIMPACT: A Prospective Real-World Study of Atezolizumab Monotherapy as First-Line (Stage IV) Treatment in Patients With Non-Small Cell Lung Cancer With PD-L1 Tumor Cell Expression ≥50% and No Targetable Mutations

Source: ClinicalTrials.gov · Last updated 30 Apr 2026

Brief summary (registry, in English)

This prospective, multicenter, real-world observational study aims to evaluate the clinical outcomes of first-line atezolizumab monotherapy in patients with stage IV non-small cell lung cancer (NSCLC) with PD-L1 tumor cell expression ≥50% and no targetable mutations. The study aim to determine how atezolizumab performs in routine clinical practice with respect to survival, treatment response, and safety outcomes in this patient population in Türkiye.

Status (registry)
Recruiting
Study type
Observational
Enrollment
150 (estimated)
First submitted
1 Dec 2025
Start date
15 Sept 2025
Primary completion date
1 May 2027
Lead sponsor
Antalya Training and Research Hospital
Diseases
Lung cancer
NCT number
NCT07279402

What you commit to

  • Study type: Observational
  • Planned participants: 150
  • From 15 Sept 2025 to the primary completion date, 1 May 2027
  • 25 sites in 1 country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Patients who are not receiving atezolizumab for the treatment of lung cancer according to standard of care and the approved indication.

Other illness

  • Known or suspected hypersensitivity to atezolizumab.

Other

  • Pregnant or breastfeeding women.

Who the study is looking for

  • Signed informed consent form.
  • Diagnosis of stage IV non-small cell lung cancer.
  • Male or female patients aged 18 years or older.
  • Patients who have been prescribed atezolizumab in accordance with routine clinical practice and the locally approved indication in Türkiye.
  • Patients who have received up to 3 cycles of atezolizumab at the screening visit.

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (25)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Adana City Hospital
Coordinator of this site? Confirm its status
AdanaTurkey (Türkiye)Recruiting
Afyonkarahisar Health Sciences University Hospital
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AfyonkarahisarTurkey (Türkiye)Recruiting
Ankara Atatürk Sanatoryum Training and Research Hospital
Coordinator of this site? Confirm its status
AnkaraTurkey (Türkiye)Recruiting
Ankara Bilkent City Hospital
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AnkaraTurkey (Türkiye)Not yet recruiting
Ankara Oncology Training and Research Hospital
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AnkaraTurkey (Türkiye)Not yet recruiting
Memorial Ankara Hospital
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AnkaraTurkey (Türkiye)Not yet recruiting
Antalya Training and Research Hospital
Coordinator of this site? Confirm its status
AntalyaTurkey (Türkiye)Recruiting
Antalya City Hospital
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AntalyaTurkey (Türkiye)Recruiting
Adnan Menderes University Faculty of Medicine Hospital
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AydinTurkey (Türkiye)Recruiting
Dicle University Hospital
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DiyarbakırTurkey (Türkiye)Not yet recruiting
Trakya University Faculty of Medicine Hospital
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EdirneTurkey (Türkiye)Recruiting
Gaziantep City Hospital
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GaziantepTurkey (Türkiye)Recruiting
Başakşehir Çam and Sakura City Hospital
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IstanbulTurkey (Türkiye)Recruiting
Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi
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IstanbulTurkey (Türkiye)Not yet recruiting
İstanbul Medipol Mega Hospital
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IstanbulTurkey (Türkiye)Not yet recruiting
Bahçelievler Memorial Hospital
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IstanbulTurkey (Türkiye)Not yet recruiting
Ümraniye Training and Research Hospital
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IstanbulTurkey (Türkiye)Not yet recruiting
Dokuz Eylul University Faculty of Medicine Hospital
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IzmirTurkey (Türkiye)Recruiting
Ege University Hospital
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IzmirTurkey (Türkiye)Recruiting
Necmettin Erbakan University Meram Faculty of Medicine Hospital
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KonyaTurkey (Türkiye)Recruiting
Mersin University Faculty of Medicine Hospital
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MersinTurkey (Türkiye)Recruiting
Ordu State Hospital
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OrduTurkey (Türkiye)Not yet recruiting
Sakarya University Faculty of Medicine Hospital
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SakaryaTurkey (Türkiye)Recruiting
Medical Park Samsun Hospital
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SamsunTurkey (Türkiye)Not yet recruiting
Karadeniz Technical University Farabi Hospital
Coordinator of this site? Confirm its status
TrabzonTurkey (Türkiye)Recruiting

This page is information, not medical advice. Discuss any trial with your doctor.