NCT07279818Not yet recruiting
Improving Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: A Study of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure Interventions
Effectiveness of Transcutaneous Acupoints Electrical Stimulation and Auricular Acupressure on Chemotherapy Induced Peripheral Neuropathy in Children With Leukemia: a Single Blind Randomized Controlled Study
Source: ClinicalTrials.gov · Last updated 12 Dec 2025
Brief summary (registry, in English)
The goal of this clinical trial is to compare the effectiveness of Transcutaneous Acupoints Electrical Stimulation (TAES) and Auricular Acupressure (AA) on subject CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes in Children with Leukemia. The main questions it aims to answer are: 1. Does TAES and AA can improve CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes in children with Leukemia compared with self-management control group? 2. Does TAES yield improvements in CIPN symptoms, sensory function, motor and physical function, psychological, physical symptoms and quality of life outcomes that are comparable to those achieved through AA in children with leukemia? This proposed research is designed to conduct a three-arm RCT comparing TAES, AA to usual care in children with leukemia. Subjects in TAES group will receive 8 weeks TAES on four acupoints. Subjects in AA group will receive 8 weeks on four acupoints. Subjects in self-management control group will receive usual care they will receive from the hospital. These three groups will be provided with a leaflet containing self-help materials for CIPN.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 132 (estimated)
- First submitted
- 22 Nov 2025
- Start date
- 8 Dec 2025
- Primary completion date
- 30 Sept 2026
- Lead sponsor
- The Hong Kong Polytechnic University
- Diseases
- Childhood cancers
- NCT number
- NCT07279818
What you commit to
- Study type: Interventional
- Planned participants: 132
- From 8 Dec 2025 to the primary completion date, 30 Sept 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- receiving multiple cancer treatment
Other illness
- had a diagnosis of cancer in the central nervous system cancer, cancer relapse or secondary cancer
- having other neuromuscular disorders, for example, traumatic brain injury and cerebral palsy
- having other systematic diseases that cause toxicity in the peripheral nervous system, such as sickle cell disease (SCD), Guillain-Barre ́ Syndrome (GBS), anterior cutaneous nerve entrapment syndrome (ACNES), obstetric brachial plexus injury (OBPI), type I diabetes mellitus, postherpetic neuralgia (PHN), peroneal nerve injury, and reflex sympathetic dystrophy (RSD)
- contraindications to TEAS or auricular acupressure: such as having a pacemaker, skin infection, damage, or allergy to the electrodes
- suffering from mental illness or using antipsychotic drugs
Other
- acupoints areas with injuries, wounds or allodynia
- participated in any other CIPN non-pharmacological intervention programme
- having any impaired bone marrow suppression, liver or renal function
- parents and children refused to give consent.
Who the study is looking for
- age between 8 and 17 years old
- diagnosed with leukemia
- received neurotoxic chemotherapy
- have developed score 9 or above CIPN symptoms according to Pediatric Chemotherapy-Induced Neuropathy (P-CIN)
- able to communicate and read Chinese
Age in the registry: 8 years to 17 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai Children Medical Center Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.