NCT07281313Recruiting
Aphasia Physical EXercise Study: Randomized Trial
High-intensity Exercise in Stroke Recovery: Randomized Trial
Source: ClinicalTrials.gov · Last updated 19 Mar 2026
Brief summary (registry, in English)
The goal of this clinical trial is to evaluate the effects of a high-intensity exercise program on recovery in individuals with post-stroke aphasia. The high-intensity exercise program has been specifically designed for individuals with post-stroke aphasia and includes an interval training full-body workout, which can increase cardiovascular fitness, improve muscle strength and motor performance, and maximize cognitive and language gains. The main question this study aims to answer is: • Does participation in a high-intensity exercise program lead to changes in physical health, language, cognitive, motor recovery, psychological and/or psychosocial domains? Participants will be randomly assigned to either a high-intensity exercise program (target intervention) or a low-intensity exercise program (control intervention) delivered over 12-weeks in a group setting. Outcome measures will be collected once immediately after the intervention period and once during the following 12-week maintenance period to capture short- and long-term effects of the exercise program.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 120 (estimated)
- First submitted
- 25 Nov 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 31 Dec 2029
- Lead sponsor
- University of California, Berkeley
- Diseases
- Stroke
- NCT number
- NCT07281313
What you commit to
- Study type: Interventional
- Planned participants: 120
- From 1 Dec 2025 to the primary completion date, 31 Dec 2029
- 4 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior history of dementia, neurologic illness (other than stroke), or recent (last 3 years) substance abuse
Other illness
- Self-report uncontrolled cardiorespiratory and/or metabolic disorders incompatible with exercise
Other
- Significant visual or hearing disabilities (e.g., neglect, uncorrected visual or hearing loss) that interfere with testing
Who the study is looking for
- Aphasia following ischemic or hemorrhagic stroke
- Aphasia as determined by a standardized language test (Western Aphasia Battery Aphasia Quotient \< 93.8 at study intake)
- At least 6 months from the last stroke
- Proficient in English before the stroke
- At least 8 years of education
- Between the ages of 18 and 80
- Independent with ambulation without a device (single-point cane accepted)
- Medically stable with no contraindications to participate in regular physical exercise as determined by the patients' own primary care provider or other treating provider.
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (4)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of California, Berkeley Coordinator of this site? Confirm its status | Berkeley | United States | Recruiting |
| California State University, East Bay Coordinator of this site? Confirm its status | Hayward | United States | Recruiting |
| University of San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| University of California San Francisco Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.