NCT07285473Not yet recruitingPhase 2
Low-Dose Naltrexone For ME/CFS: Dose-Finding
Low-dose Naltrexone (LDN) for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Dose-Finding
Source: ClinicalTrials.gov · Last updated 8 Oct 2026
Brief summary (registry, in English)
This exploratory clinical trial tests low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). A remote trial approach is used, with eligibility open to the state of Alabama.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 75 (estimated)
- First submitted
- 9 Dec 2025
- Start date
- 1 Nov 2026
- Primary completion date
- 1 Apr 2028
- Lead sponsor
- University of Alabama at Birmingham
- Diseases
- Long COVID and ME/CFS
- NCT number
- NCT07285473
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 75
- From 1 Nov 2026 to the primary completion date, 1 Apr 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Evidence of active or chronic systemic infection
- Auto-immune disorder
Lab values
- Abnormal complete blood count
Other
- Abnormal hepatic function
- Abnormal renal function
- A1C \> 9.0%
- Current opioid analgesic use
- Pregnant or plans to become pregnant during the study participation period
- Enrolled in other experimental treatment study
Who the study is looking for
- Between ages of 18 and 65
- Living in Alabama
- Meets ME-ICC criteria
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Alabama at Birmingham Coordinator of this site? Confirm its status | Birmingham | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.