NCT07285642Recruiting
Brain and Peripheral Muscle Oxygenation in Patients With Chronic Obstructive Pulmonary Disease
Source: ClinicalTrials.gov · Last updated 15 Apr 2026
Brief summary (registry, in English)
This interventional study aims to investigate the acute effects of different types of exercise on cerebral and peripheral muscle oxygenation in patients with chronic obstructive pulmonary disease (COPD). Functional near-infrared spectroscopy (fNIRS) and near-infrared spectroscopy (NIRS) will be used simultaneously to measure oxygenation changes in the prefrontal cortex and the vastus lateralis muscle during rest, Stroop task performance, the six-minute walk test, aerobic, strengthening, and breathing exercises. The study will compare COPD patients and age- and sex-matched healthy controls to determine how brain and muscle oxygenation responses differ between groups and among exercise modalities. The findings are expected to guide the design of safe, individualized pulmonary rehabilitation programs that optimize oxygenation without compromising safety.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 20 Nov 2025
- Start date
- 30 Apr 2025
- Primary completion date
- 1 Nov 2026
- Lead sponsor
- Saglik Bilimleri Universitesi
- Diseases
- COPD
- NCT number
- NCT07285642
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 30 Apr 2025 to the primary completion date, 1 Nov 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Need for high-flow oxygen therapy (\>2 L/min)
Other illness
- Severe comorbid conditions (uncontrolled cardiac, neurological, or orthopedic disease)
- History of cerebrovascular disease or transient ischemic attack
- Musculoskeletal or dermatological conditions impairing NIRS measurement sites
- Restrictive lung disease, interstitial lung disease, or small-airway disease
- No acute or chronic disease
Age
- Age 40-70 years
Other
- Participation in an exercise program within the last 12 months
- Healthy Controls
- Non-smoker
- BMI 18.5-24.9 kg/m²
- No musculoskeletal limitations
Who the study is looking for
- Age 40-70 years
- Diagnosis of moderate-to-severe COPD (GOLD stage II-III)
- Stable disease (no exacerbation in previous 4 weeks)
- BMI 18.5-24.9 kg/m²
- Manual muscle strength ≥ 4 (MRC scale)
- Ability to perform exercise tests safely
- Written informed consent
Age in the registry: 40 years to 70 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Esra Pehlivan Coordinator of this site? Confirm its status | Istanbul | Turkey (Türkiye) | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.