NCT07294963Completed
Impact of Lifestyle Interventions on Cognitive Decline in Non-alcoholic Fatty Liver Disease
Impact of Lifestyle Interventions on Cognitive Decline in NAFLD: A Randomized Controlled Trial of Liver Fibrosis, Hormonal Imbalance, and Inflammatory Markers
Source: ClinicalTrials.gov · Last updated 18 Aug 2026
Brief summary (registry, in English)
This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 45 (actual)
- First submitted
- 8 Dec 2025
- Start date
- 1 Oct 2025
- Primary completion date
- 28 Apr 2026
- Lead sponsor
- Khyber Medical University Peshawar
- Diseases
- Fatty liver disease (MASLD/MASH)
- NCT number
- NCT07294963
What you commit to
- Study type: Interventional
- Participants enrolled: 45
- From 1 Oct 2025 to the primary completion date, 28 Apr 2026
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of alcohol intake \>20g/day.
- Chronic viral hepatitis B or C.
- Major neuropsychiatric illnesses.
- Chronic illnesses including Diabetes Mellitus and thyroid dysfunction.
Other
- Pregnancy or breastfeeding.
Who the study is looking for
- Age 18 to 42 years.
- Diagnosed with fatty liver (NAFLD) via imaging (e.g., ultrasound).
- Liver fibrosis assessed and staged via FibroScan and the FIB-4 index.
- Literate (to consent and complete cognitive assessments/questionnaires).
Age in the registry: 18 years to 42 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Khyber Teaching Hospital Coordinator of this site? Confirm its status | Peshawar | Pakistan | Unknown status |
| Northwest General Hospital Coordinator of this site? Confirm its status | Peshawar | Pakistan | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.