NCT07298057RecruitingEarly phase 1
Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics
Effectiveness of Scaling and Root Planing With and Without Minocycline Microspheres (Arestin) in Improving Periodontal and Glycemic Outcomes in Diabetic Patients With Periodontitis: A Randomized Controlled Trial
Source: ClinicalTrials.gov · Last updated 19 Feb 2026
Brief summary (registry, in English)
Periodontitis is a prevalent chronic inflammatory disease that exacerbates systemic inflammation and poses challenges for glycemic control in diabetic patients. While scaling and root planing (SRP) remains the cornerstone of periodontal therapy, adjunctive treatments such as Arestin (minocycline microspheres) have shown promise in enhancing clinical outcomes. This study aims to evaluate the impact of adding Arestin to SRP on periodontal pocket closure, glycemic control, and systemic inflammation in diabetic patients with periodontitis.
- Status (registry)
- Recruiting
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 42 (estimated)
- First submitted
- 11 Dec 2025
- Start date
- 6 Feb 2026
- Primary completion date
- Jun 2027
- Lead sponsor
- Case Western Reserve University
- Diseases
- Type 2 diabetes
- NCT number
- NCT07298057
What you commit to
- Study type: Interventional · Early phase 1
- Planned participants: 42
- From 6 Feb 2026 to the primary completion date, Jun 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Allergy to minocycline or tetracycline
- Smokers or patients with poorly controlled systemic diseases other than diabetes
Other
- Unable to receive or to tolerate local anesthesia
- Unable to tolerate tooth instrumentation with ultrasonic instruments.
- Require IV sedation to receive scaling and root planing
- Use of antibiotics within the past 3 months
- Pregnancy or breastfeeding
- Morbid Obesity (BMI 40+)
Who the study is looking for
- Adults (≥18 years) with type 2 diabetes mellitus (HbA1c ≥ 7.0% and ≤9.5%)
- Diagnosed with moderate to severe periodontitis (≥5 mm probing pocket depth in at least 6 distinct interproximal sites, on different teeth)
- At least 16 teeth present
- No periodontal treatment in the last 6 months
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Case Western Reserve University Coordinator of this site? Confirm its status | Cleveland | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.