NCT07299292RecruitingPhase 2
Castration With Abiraterone 250 mg Without LHRH Analogs or Blockers in Patients With Prostate Cancer Requiring Hormonal Intensification (Multicenter Phase 2)
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
Hypothesis The use of Abiraterone 250 mg with food + prednisone, without LHRH analogs or blockers (ADT), achieves castration-level testosterone at 30 days in ≥80-90% of cases.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 9 Dec 2025
- Start date
- 1 Dec 2025
- Primary completion date
- 31 Dec 2026
- Lead sponsor
- SMED Clinical Research
- Diseases
- Prostate cancer
- NCT number
- NCT07299292
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 60
- From 1 Dec 2025 to the primary completion date, 31 Dec 2026
- 3 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study design.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent therapy with strongly contraindicated/inducing drugs affecting ABI levels without possibility of adjustment.
Other illness
- Hypersensitivity to ABI/prednisone; moderate-severe hepatic impairment; uncontrolled hypertension; refractory hypokalemia.
Who the study is looking for
- Age ≥18 years.
- Histologically confirmed prostate adenocarcinoma.
- Treated at Hospital Durand (Argentina) or Instituto Oncológico del Oriente Boliviano (Bolivia).
- Indicated for hormonal intensification (high/very high risk candidates for RT, or mHSPC for doublet/triplet).
- No prior ADT.
- ECOG 0-2; adequate hepatic/renal function; K+ ≥3.5 mmol/L; controlled BP.
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hospital Carlos A Durand Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Recruiting |
| Hospital San José Coordinator of this site? Confirm its status | Hermosillo | Spain | Not yet recruiting |
| Instituto Oriente Boliviano Coordinator of this site? Confirm its status | Santa Cruz de la Sierra | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.