NCT07299981Recruiting
Quantitative Net Water Uptake as a Predictor of Functional Outcomes After Intravenous Thrombolysis in Acute Ischemic Stroke International Multicenter Observational Retrospective Study
Source: ClinicalTrials.gov · Last updated 16 Jul 2026
Brief summary (registry, in English)
While the effectiveness of intravenous thrombolysis (IVT) decreases over time, patients show considerable variability in how quickly their ischemic core progresses. Quantitative net water uptake (NWU) has emerged as a biomarker indicating blood-brain barrier disruption and may better reflect the "tissue clock" than time alone. Low NWU is associated with favorable outcomes, whereas high NWU predicts poor outcomes and futile recanalization. The study aims to determine whether NWU measured on initial non-contrast CT is a treatment effect modifier for the IVT therapy.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 200 (estimated)
- First submitted
- 10 Dec 2025
- Start date
- 1 Feb 2026
- Primary completion date
- 1 Apr 2027
- Lead sponsor
- Sigmund Freud PrivatUniversitat
- Diseases
- Stroke
- NCT number
- NCT07299981
What you commit to
- Study type: Observational
- Planned participants: 200
- From 1 Feb 2026 to the primary completion date, 1 Apr 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Known use of oral anticoagulation (OAC) on admission
- Preexisting ischemic infarction on admission non-contrast cranial CT
- Patients with large vessel occlusion AIS who underwent mechanical thrombectomy
- Low imaging quality precluding radiological measurements
- Severe white matter lesions precluding radiological measurements
- No ASPECTS
Who the study is looking for
- Acute ischemic stroke treated with intravenous thrombolysis
- Imaging with non-contrast cranial CT on admission
- Follow-up imaging with non-contrast cranial CT or MRI 12-24 hours after IVT
- Final Infarct volume \> 5ml
- ASPECTS available
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Department of Neurology, St. John's Hospital, Vienna, Austria, Vienna, 1020 Coordinator of this site? Confirm its status | Vienna | Austria | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.