NCT07300111Not yet recruitingPhase 3
A Study to Evaluate Efficacy and Safety of QLG1218(Daprodustat) in Chinese Hemodialysis (HD)-Dependent Subjects With Anemia Associated With Chronic Kidney Disease (CKD)
A Randomized, Open Label, Active-controlled, Parallel-group, Multi-center Study to Evaluate Efficacy and Safety of QLG1218(Daprodustat) in Chinese Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease.
Source: ClinicalTrials.gov · Last updated 23 Dec 2025
Brief summary (registry, in English)
This study is to evaluate the efficacy and safety of QLG1218(daprodustat) following a switch from erythropoiesis-stimulating agent (ESA) in Chinese HD subjects with renal anemia who are currently treated with ESA. The primary objective is to demonstrate non-inferiority of QLG1218 to darbepoetin alfa. This study is a randomized, open Label, active-controlled, parallel-group, multi-center Study. The total duration of the study will be approximately 32 weeks including screening and follow-up.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 100 (estimated)
- First submitted
- 10 Dec 2025
- Start date
- 31 Dec 2025
- Primary completion date
- May 2027
- Lead sponsor
- Qilu Pharmaceutical Co., Ltd.
- Diseases
- Chronic kidney disease
- NCT number
- NCT07300111
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 100
- From 31 Dec 2025 to the primary completion date, May 2027
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Evidence of actively bleeding gastric, duodenal, or esophageal ulcer disease OR clinically significant GI bleeding within 12 weeks prior to screening or during a period from screening to Day 1.
- Myocardial infarction, acute coronary syndrome, stroke, or transient ischemic attack: Diagnosed within 12 weeks prior to screening or during a period from screening to Day 1
- History of severe allergic or anaphylactic reactions or hypersensitivity to excipients in the investigational product.
- Use or planned use of any prescription or non-prescription drugs or dietary supplements that are prohibited during the study period.
- Use of an investigational agent within 30 days or five half lives of the investigational agent (whichever is longer)
- Use of daprodustat or other HIF-PHI within 4 weeks prior to screening, or any prior treatment with daprodustat for a treatment duration of \> 4weeks.
Other illness
- History of bone-marrow hypoplasia, pure red cell aplasia, pernicious anemia, thalassemia, sickle cell anemia, or myelodysplastic syndromes.
- History of malignancy.
- Chronic Class III or IV heart failure, as defined by the New York Heart Association (NYHA) functional classification system.
- poorly controlled hypertension.
- Current unstable active liver or biliary disease.
Lab values
- QTc \>500 milliseconds (msec); or QTc \>530 msec in subjects with bundle branch block.
- ALT or AST \>2 upper limit of normal (ULN)，or bilirubin \>1.5×ULN.
Who the study is looking for
- Female or male，age 18 to 75
- Weight 45 to 100 kg
- Receiving hemodialysis (including hemodiafiltration) consistently three times a week for at least 12 weeks prior to screening.
- Patients with pre-dialysis Hb levels measured after the maximum interdialytic interval at Scr Visit 1 and Scr Visit 2 (1 week after the start of observation) of ≥95 g/L and \<120 g/L and a difference (in absolute value) between Scr Visit 1 and Scr Visit 2 of ≤15 g/L.
- TSAT \>20% and ferritin \>100 μg/L
- Use of one and the same ESA for 10 weeks prior to screening
- Darbepoetin alfa 10 to 60 μg per week, epoetin (including biosimilars) 1500 to 10000 international units (IU) per week.
Age in the registry: 18 years to 75 years · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.