NCT07302425Recruiting
High-intensity Resistance Training in Post-exacerbation COPD
The Effect of the High-intensity Resistance Training in COPD Patients Recovering From Hospital Exacerbation: a Pilot Study
Source: ClinicalTrials.gov · Last updated 24 Dec 2025
Brief summary (registry, in English)
After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 64 (estimated)
- First submitted
- 21 Nov 2025
- Start date
- 30 Oct 2025
- Primary completion date
- 31 Oct 2027
- Lead sponsor
- Istituti Clinici Scientifici Maugeri SpA
- Diseases
- COPD
- NCT number
- NCT07302425
What you commit to
- Study type: Interventional
- Planned participants: 64
- From 30 Oct 2025 to the primary completion date, 31 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of lung diseases other than COPD
- Orthopedic and neurological conditions that prevent the execution of functional tests
- Severe neurological and cardiologic comorbidities or other severe diseases compromise exercise tolerance.
- Cognitive impairment evaluated by Mini-Mental State Examination (MMSE) score as \< 25.
Who the study is looking for
- COPD diagnosis according to the GOLD guidelines \[11\] with FEV1/FVC \<70%
- Stable clinical condition (pH\>7.30) \[11\]
- Hospital discharge within 3 weeks from an event of hospitalization due to an acute exacerbation of COPD.
- Absence of significant motor disability, described by the possibility of performing the 6MWT.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ICS Maugeri IRCCS, Respiratory Rehabilitation of the Institute of Lumezzane Coordinator of this site? Confirm its status | Lumezzane | Italy | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.