NCT07303257Recruiting
Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options
Quality of Life After Glaucoma Surgery: Evaluating the Patient Perspective Across Surgical Options - G-SCOPE (Glaucoma Surgery - Comparative Patient Evaluation)
Source: ClinicalTrials.gov · Last updated 16 Mar 2026
Brief summary (registry, in English)
Glaucoma surgery currently relies on a wide therapeutic arsenal, ranging from conventional filtering surgeries to minimally invasive glaucoma surgery (MIGS). These techniques offer distinct efficacy and safety profiles, allowing tailored management across a broad spectrum of patients. Traditionally, surgical success has been evaluated using objective clinical outcomes, such as intraocular pressure (IOP) reduction and decreased reliance on topical treatments. However, the shift toward patient-centered medicine now requires consideration of the patient's perspective, including their subjective experience and the impact of treatment on quality of life. In this context, quality-of-life assessment has become a key component, promoting therapeutic alliance and patient adherence to care pathways. Despite its importance, few studies have evaluated and compared quality of life after glaucoma surgery using comparable surgical techniques. Furthermore, to our knowledge, no study has specifically assessed the independent effect of postoperative follow-up on quality of life after filtering surgery with a bleb. Given that postoperative management can be prolonged and demanding, it may significantly influence patients' perceptions of surgical outcomes and overall well-being. This study aims to address these gaps by providing a more comprehensive evaluation of the impact of glaucoma surgery beyond traditional clinical outcomes. It may represent a first step toward the development of a more appropriate assessment tool that incorporates the realities of postoperative follow-up and the specific experiences of patients undergoing filtering surgery. The study is based on the following hypotheses: filtering glaucoma surgery preserves patients' quality of life, with a stable NEI VFQ-25 score at six months postoperatively; postoperative quality of life may be influenced by the patient's postoperative care pathway; and quality-of-life scores remain correlated with objective clinical parameters, including intraocular pressure, visual acuity, medical treatment burden, and visual field damage.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 132 (estimated)
- First submitted
- 11 Dec 2025
- Start date
- 23 Feb 2026
- Primary completion date
- Aug 2027
- Lead sponsor
- Hospices Civils de Lyon
- Diseases
- Glaucoma
- NCT number
- NCT07303257
What you commit to
- Study type: Observational
- Planned participants: 132
- From 23 Feb 2026 to the primary completion date, Aug 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Refractory glaucoma with a history of multiple previous surgeries
- Ophthalmologic surgery within 6 months prior to inclusion
Other illness
- Patients with a significant pre-existing impairment in quality of life attributable to a progressive physical illness or a neuropsychiatric disorder.
Age
- Severe visual co-morbidities (age-related macular degeneration, severe diabetic retinopathy, retinal degeneration, or similar conditions)
Other
- Congenital glaucoma
- Expected difficulty with follow-up including poor anticipated compliance, planned travel or prolonged absence during the follow-up period
- Illiteracy, inability to speak French or impaired cognitive capacity preventing adequate understanding of the study
- Patients under curatorship or guardianship
- Pregnant women
Who the study is looking for
- Patient aged ≥ 18 years with an indication for glaucoma surgical treatment
- Eligible surgical procedures: Preserflo™ MicroShunt with mitomycin C, Trabeculectomy with mitomycin C or non-penetrating deep sclerectomy with mitomycin C
- Unilateral or bilateral glaucoma, open-angle or angle-closure, at early, moderate, or advanced stages
- Pseudoxexfoliative or pigmentary glaucoma
- Secondary glaucoma, including: uveitic glaucoma, Steroid-induced glaucoma, traumatic glaucoma
- Written informed consent obtained prior to study participation
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Service d'Ophtalmologie, Hôpital de La Croix Rousse, Hospices Civils de Lyon Coordinator of this site? Confirm its status | Lyon | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.