NCT07307768WithdrawnPhase 1
Ketamine Biomarker Validation
EEG Biomarker Development for Ketamine Administration
Source: ClinicalTrials.gov · Last updated 19 Oct 2026
Reason given: Funding was not provided
Brief summary (registry, in English)
An EEG-based biomarker will be developed for the effects of ketamine infusion in patients with Depression. The effects of ketamine infusion on Depression symptoms and EEG signals will be analyzed.
- Status (registry)
- Withdrawn
- Phase (registry)
- Phase 1
- Study type
- Interventional
- Enrollment
- 0 (actual)
- First submitted
- 15 Dec 2025
- Start date
- 20 Dec 2025
- Primary completion date
- 1 Dec 2027
- Lead sponsor
- Soterix Medical
- Diseases
- Depression
- NCT number
- NCT07307768
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Receipt of electroconvulsive therapy within 3 months of enrolling in the study
- Nonresponse or intolerance to ketamine administered either clinically or as part of a prior research study
- No antipsychotics or medications (e.g. benzodiazepines, anti-epileptics) that are likely to interact with GABA or glutamate,
Other illness
- Lifetime history of bipolar disorder, schizoaffective disorder, schizophrenia, or any other psychotic disorder, including MDD with psychotic features
- History of IV drug use
Age
- A first-degree relative with bipolar disorder, schizoaffective disorder, or schizophrenia, with the potential participant younger than 33 years (i.e., still at age of risk for a psychotic disorder)
Other
- Pregnancy, planning to conceive, or sexually active but not using adequate birth control.
- Actively suicidal (CSSRS≥3)
Who the study is looking for
- Physically healthy patients who meet DMS-5 criteria for a major depressive episode (MDE) in the context of MDD and who score at least 22 on the Montgomery-Åsberg Depression Rating Scale (MADRS)
- If taking antidepressants, dose is stable for at least 6 weeks.
Age in the registry: 18 years to 59 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Columbia University Irving Medical Center | New York | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.