NCT07308990Recruiting
Limited Versus Extended Lymph Node Dissection During Radical Prostatectomy in Patients With Localized or Locally Advanced Prostate Cancer
To Develop and Implement a Method for Optimizing the Volume of Lymph Node Dissection in Radical Surgical Treatment of Localized or Locally Advanced Prostate Cancer
Source: ClinicalTrials.gov · Last updated 30 Dec 2025
Brief summary (registry, in English)
This is a randomized controlled study assessing outcome of low (no or limited) versus high (limited or extended) extent of lymph node dissection in addition to radical prostatectomy in patients with operable localized or locally advanced prostate cancer.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 800 (estimated)
- First submitted
- 2 Dec 2025
- Start date
- Oct 2025
- Primary completion date
- May 2030
- Lead sponsor
- N.N. Alexandrov National Cancer Centre
- Diseases
- Prostate cancer
- NCT number
- NCT07308990
What you commit to
- Study type: Interventional
- Planned participants: 800
- From Oct 2025 to the primary completion date, May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Severe concomitant disease limiting participation in the study.
Other illness
- Presence of another active malignant invasive neoplasm.
- Contraindication to pelvic lymph node dissection (e.g., history of radiation therapy to the pelvis).
Other
- The evidence of metastases in regional lymph nodes according to preoperative examination data (including PET/CT with PSMA).
Who the study is looking for
- Age over 18 years.
- Histologically confirmed localized or locally advanced prostate cancer (adenocarcinoma without a neuroendocrine component).
- No evidence of metastatic spread of the tumor
- Local resectability of the tumor according to digital rectal examination and/or CT and/or MRI of the pelvis
- Patients are suitable for radical prostatectomy based on their comorbidities and life expectancy.
- Signed informed consent to participate in the study.
Age in the registry: 18 years to - · Sex: Male · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| N.N. Alexandrov National Cancer Centre Coordinator of this site? Confirm its status | Lyasny | Belarus | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.