NCT07309198Completed
Temporal Interference Stimulation on Motor Symptoms in Parkinson's Disease
Effects and Mechanisms of Non-invasive Deep Brain Stimulation in Patients With Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 24 Jun 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn whether a type of brain stimulation called transcranial temporal interference stimulation (TIS) of the internal globus pallidus (GPi) can help improve movement symptoms in people with Parkinson's disease. The study will also look at how TIS changes brain activity related to these improvements. The main questions this study aims to answer are: * How much can repeated TIS sessions improve movement symptoms in people with Parkinson's disease? * Can these improvements last for up to two months after the treatment ends? * What changes in brain activity happen along with the improvements? Researchers will compare people who receive active TIS with those who receive sham (placebo-like) stimulation to see whether active TIS leads to better movement outcomes. Participants will: * Receive 10 sessions of active or sham TIS over two weeks * Complete movement assessments during the two-week treatment and again 2, 4, and 8 weeks afterward * Complete brain activity assessments before and after the two-week treatment
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 37 (actual)
- First submitted
- 15 Nov 2025
- Start date
- 29 Dec 2025
- Primary completion date
- 15 Apr 2026
- Lead sponsor
- Shanghai University of Sport
- Diseases
- Parkinson disease
- NCT number
- NCT07309198
What you commit to
- Study type: Interventional
- Participants enrolled: 37
- From 29 Dec 2025 to the primary completion date, 15 Apr 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of antipsychotic, antidepressant, or other dopamine-modulating medications.
- Prior history of deep brain stimulation (DBS) surgery.
Other illness
- Any contraindication for MRI or transcranial temporal interference stimulation (TIS), including claustrophobia, metallic implants in the head or heart, or a history of electroconvulsive therapy.
- Presence of orthopedic conditions that may interfere with motor assessments, such as osteoarthritis or recent orthopedic surgery (within the past 6 months).
- History of physician-diagnosed major psychiatric illness.
Other
- Physician-diagnosed cardiovascular risks that could contraindicate exercise or study participation.
Who the study is looking for
- A physician-diagnosed idiopathic Parkinson's disease (PD) according to the Movement Disorder Society (MDS) diagnostic criteria, with onset after the age of 40.
- Stable antiparkinsonian medication regimen, including levodopa-containing therapy, unchanged for at least 4 weeks before and during the trial.
- Hoehn and Yahr (H\&Y) stages 1.5 to 3 and ability to walk unassisted.
- Absence of dementia, defined as a Montreal Cognitive Assessment (MoCA) score ≥ 21.
Age in the registry: 40 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shanghai University of Sport Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.